Abstract
Eukaryotic translation initiation factor 3 subunit A (eIF3a) plays critical roles in regulating the initiation of protein translation, and eIF3a is highly expressed in lung cancer. In this study, we investigated the association of the positively selected SNPs of eIF3a with the response to and toxicity of platinum-based chemotherapy in Chinese patients with non-small cell lung cancer (NSCLC). SNP data for eIF3a locus were downloaded from HapMap database. For each SNP, haplotype, LD profile and population differentiation were analyzed. The long-range haplotype (LRH) test was employed to identify positively selected SNPs of eIF3a. A total of 325 NSCLC patients were enrolled and genotyped for these SNPs. Five positively selected (rs1409314, rs4752219, rs4752220, rs7091672 and rs10510050) and 5 non-positively selected SNPs (rs10886342, rs11198804, rs2275112, rs10787899 and rs4752269) were identified in the LRH test. However, none of them was correlated with the platinum-based chemotherapy response. In contrast, 4 of the positively selected SNPs (rs1409314, rs4752219, rs4752220 and rs7091672) were significantly correlated with the toxicities tested (neutropenia, anemia, thrombocytopenia, emesis and hepatotoxicity). In addition, rs105...Continue Reading
References
Jan 10, 1998·The Journal of Biological Chemistry·J ChaudhuriU Maitra
Jun 17, 1998·Nucleic Acids Research·E BurattiF E Baralle
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Jun 1, 2001·British Journal of Cancer·R PincheiraJ T Zhang
May 25, 2002·Human Molecular Genetics·Thomas G SchulzeFrancis J McMahon
Oct 25, 2002·Nature·Pardis C SabetiEric S Lander
Dec 6, 2002·Genome Research·Joshua M AkeyMark D Shriver
Dec 21, 2002·Science·Noah A RosenbergMarcus W Feldman
Feb 1, 2003·Nature Reviews. Genetics·Michael Bamshad, Stephen P Wooding
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Feb 21, 2004·Human Molecular Genetics·Kun TangCaroline G L Lee
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jul 1, 2006·Trends in Genetics : TIG·Shameek Biswas, Joshua M Akey
Jul 11, 2006·Critical Reviews in Oncology/hematology·Zizheng Dong, Jian-Ting Zhang
Apr 7, 2007·Human Molecular Genetics·Zihua WangCaroline G L Lee
Feb 28, 2008·Pharmacogenetics and Genomics·Keyue Ding, Iftikhar J Kullo
Apr 21, 2009·Breast Cancer Research and Treatment·J E OlsonF J Couch
Dec 19, 2009·Environmental Health Perspectives·Xiaoping ChenFuchu He
Oct 23, 2010·Bioscience Reports·Ji-Ye YinJian-Ting Zhang
May 14, 2011·Molecular Ecology Resources·Laurent Excoffier, Heidi E L Lischer
May 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ji-Ye YinZhao-Qian Liu
Jul 19, 2012·British Journal of Clinical Pharmacology·Xiaojing XuZhaoqian Liu
Nov 7, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xiaojing XuZhaoqian Liu
Feb 9, 2013·Carcinogenesis·Ji-Ye YinJian-Ting Zhang
Mar 20, 2014·PloS One·Ying WangZhao-Qian Liu
Apr 2, 2014·Clinical and Experimental Pharmacology & Physiology·Ying WangZhao-Qian Liu
May 24, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiang-Ping LiZhao-Qian Liu
Citations
Apr 30, 2016·Cancer Letters·Ji-Ye YinZhao-Qian Liu
Jul 28, 2016·Pharmacogenomics·Ji-Ye YinZhao-Qian Liu
Sep 4, 2016·Chinese Journal of Cancer·Chen-Yue QianZhao-Qian Liu
Oct 30, 2016·Clinical Genetics·T ZouZ Liu
Jan 18, 2017·Chinese Journal of Cancer·Jun-Yan LiuJi-Ye Yin
Dec 12, 2018·Scientific Data·Lei-Yun WangJi-Ye Yin
Mar 28, 2019·Expert Review of Clinical Pharmacology·Ramón CacabelosJuan C Carril
Oct 16, 2019·Molecular Genetics and Genomics : MGG·Jyoti RoyBibekanand Mallick
Jul 28, 2015·Oncotarget·Yu ZhangZhao-Qian Liu
Apr 1, 2017·The Kaohsiung Journal of Medical Sciences·Jia-Zhen XuXian-Rong Wang
Jul 13, 2017·Scientific Reports·Jia-Jia CuiJi-Ye Yin
Dec 12, 2018·Journal of Cellular Physiology·Feng LvAi-Jun Sun
Jun 15, 2019·Cancer Medicine·Ma-Sha HuangZhao-Qian Liu
Nov 24, 2020·Aging·Zhuo-Miao YeYou-Ming Tang