Association of posterior p-values of S.A.G.E. SIBPAL proportion-IBD and Haseman-Elston statistics for ACTHR112

Genetic Epidemiology
D GordonT G Marr

Abstract

A common practice among researchers performing linkage studies is the use of equal allele frequencies as input when reporting p-values from computer linkage programs such as S.A.G.E. SIBPAL. Our results, using 5,000 sets from a uniform-prior distribution of allele frequencies, showed that such input may be problematic. Further, we found that the S.A.G.E. SIBPAL test for proportion of alleles shared identical by descent among concordantly affected sib pairs showed a greater percentage of significant p-values with decreasing parental genotype information (Table III), while the S.A.G.E. SIBPAL Haseman-Elston test produced significant p-values comparatively less frequently (Table IV).

References

Mar 1, 1972·Behavior Genetics·J K Haseman, R C Elston
Jan 1, 1995·Human Heredity·D E Weeks, L D Harby
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·W H BerrettiniE S Gershon
Jan 1, 1993·Genetic Epidemiology·M C BabronF Clerget-Darpoux
Apr 1, 1996·Nature Genetics·N Risch, D Botstein

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Citations

Dec 22, 1999·Genetic Epidemiology·T M KingG P Page
Dec 22, 1999·Genetic Epidemiology·H K TiwariV George
Dec 22, 1999·Genetic Epidemiology·D F Wyszynski, C I Panhuysen
Dec 22, 1999·Genetic Epidemiology·D R GoldsteinC J Etzel
Dec 22, 1999·Genetic Epidemiology·R GuerraS R Sain

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