Association of Postoperative Antibiotics With Surgical Site Infection in Mohs Micrographic Surgery

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Ethan C LevinSarah T Arron

Abstract

Surgical site infection (SSI) is the most frequent complication of Mohs micrographic surgery. Previous studies have identified risk factors for SSI, but it is not known whether antibiotic prophylaxis mitigates this risk. To measure the association between antibiotic prophylaxis and SSI in a convenience sample of Mohs cases and to report on the utility of propensity scoring to control for confounding by indication in registry data. Data were drawn from a pilot quality improvement registry of 816 Mohs cases. The relationship between antibiotic prophylaxis and SSI was assessed with logistic regression modeling using propensity score methods to adjust for confounding. One hundred fifty-one cases were prescribed antibiotic prophylaxis (18.5%). Of 467 cases with follow-up, 16 (3.4%) developed SSI. Infection rates were higher in subjects prescribed prophylaxis, but propensity adjustment reduced this effect. Adjusted odds of infection were 1.47-fold higher in subjects prescribed antibiotics and not statistically significant (95% confidence interval 0.29-7.39; p = .64). Although there was no significant difference in SSI among patients prescribed prophylactic antibiotics, statistical precision was limited by the low incidence of infecti...Continue Reading

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Citations

Dec 14, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·T J WillenbrinkC M Proby
May 14, 2020·The Laryngoscope·Matthew Q MillerJ Jared Christophel
Oct 3, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·John S BarbieriJeremy R Etzkorn
Jul 13, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Harvey SmithCarl Vinciullo
Jun 3, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Joshua SchimmelAshley Decker
Aug 17, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kathleen M NemerEva A Hurst
Jan 26, 2021·Journal of the American Academy of Dermatology·Allen G StricklerDésirée Ratner
Apr 3, 2021·American Journal of Clinical Dermatology·Gabrielle Schwartzman, Amor Khachemoune
Apr 15, 2021·Anais Brasileiros De Dermatologia·Guilherme Canho BittnerStanislav N Tolkachjov
Nov 25, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Eva B NiklinskaAllison Hanlon

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