Association of pre-eclampsia with hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Hülya YilmazTurgay Isbir

Abstract

Hyperhomocysteinaemia is a common finding in a wide variety of pathological conditions that exhibit endothelial disturbances. In the pathogenesis of pre-eclampsia, endothelial cell activation or dysfunction has been proposed as a central feature, and the presence of hyperhomocysteinaemia in varying degrees has been detected. One of the known causes of hyperhomocysteinaemia is polymorphism in the methylenetetrahydrofolate reductase gene that lowers the activity of the enzyme. In the current study, we measured plasma homocysteine concentrations in pre-eclamptic pregnants, and searched for the altered methylenetetrahydrofolate reductase (MTHFR) gene in which the cytosine 677 was replaced by the thymine (C677T polymorphism). The study groups consisted of 64 pre-eclamptic and 47 normotensive healthy pregnant women in their third trimester. The C677T transition in the MTHFR gene was detected by HinfI restriction enzyme analysis and subsequent electrophoresis in a 3% agarose gel. Total homocysteine concentrations were measured by high performance liquid chromatography. The prevalence of the homozygous mutant thymine-thymine genotype was non-significant in the pre-eclamptic group. Total homocysteine in the plasma of pre-eclamptic women...Continue Reading

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Citations

Aug 24, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiao-ping XiaYun-xia Cao
Jan 10, 2013·Human Reproduction Update·A J BuurmaH J Baelde
Jan 11, 2008·Journal of Perinatal Medicine·Sabine MützeWerner Rath
Oct 18, 2013·The Proceedings of the Nutrition Society·R ReillyM Ward
Mar 12, 2005·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Heike Varnholt
Mar 12, 2015·Journal of Assisted Reproduction and Genetics·Xiaoming WuWenru Tang
Aug 28, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jingyuan HouLiubing Lan
Nov 14, 2006·Current Opinion in Obstetrics & Gynecology

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