Association of prealbumin level with mortality in patients with acute kidney injury

Nature Clinical Practice. Nephrology
Patrick T Murray

Abstract

Acute kidney injury (AKI) is common in hospitalized patients, a population with a high prevalence of malnutrition. Pre-existing malnutrition is associated with adverse outcomes in patients with AKI. This Practice Point commentary discusses a study by Perez Valdevieso et al. that examined the association between serum prealbumin level and mortality in patients with AKI. Adjusted multivariate analyses showed that a serum prealbumin level below the group median (11 mg/dl) was independently predictive of in-hospital mortality and that for every 5 mg/dl increase in serum prealbumin level, in-hospital mortality decreased by 29%. A decreased serum prealbumin concentration at the time of renal consultation for AKI independently predicted poor prognosis. It is unknown whether this adverse prognostic association is primarily caused by malnutrition, a negative acute phase response to inflammation, transcapillary leak, or a combination of factors. Serum prealbumin levels may aid prognostic stratification and clinical decision making in AKI and should be included in future studies. There is no evidence that attempting to raise low prealbumin levels through aggressive nutritional support improves outcomes in AKI.

References

Mar 12, 1999·Journal of the American Society of Nephrology : JASN·E FiaccadoriA Borghetti
Apr 17, 2004·Kidney International·Edith M SimmonsUNKNOWN PICARD Study Group
Dec 1, 2005·Kidney International·Glenn M ChertowGeorge A Kaysen
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·N CanoUNKNOWN ESPEN (European Society for Parenteral and Enteral Nutrition)
Jul 28, 2007·Journal of the American Society of Nephrology : JASN·Noël J M CanoUNKNOWN French Study Group for Nutrition in Dialysis
Mar 7, 2008·Kidney International·K KirylukR Isom
Apr 16, 2008·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Jose Ramon Perez ValdiviesoFrancisco Javier Lavilla
Jun 13, 2008·Journal of the American Geriatrics Society·Richard A DennisDennis H Sullivan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.