Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant.

Frontiers in Immunology
L E HigdonJ S Maltzman

Abstract

Immune function is altered with increasing age. Infection with cytomegalovirus (CMV) accelerates age-related immunological changes resulting in expanded oligoclonal memory CD8 T cell populations with impaired proliferation, signaling, and cytokine production. As a consequence, elderly CMV seropositive (CMV+) individuals have increased mortality and impaired responses to other infections in comparison to seronegative (CMV-) individuals of the same age. CMV is also a significant complication after organ transplantation, and recent studies have shown that CMV-associated expansion of memory T cells is accelerated after transplantation. Thus, we investigated whether immune aging is accelerated post-transplant, using a combination of telomere length, flow cytometry phenotyping, and single cell RNA sequencing. Telomere length decreased slightly in the first year after transplantation in a subset of both CMV+ and CMV- recipients with a strong concordance between CD57+ cells and short telomeres. Phenotypically aged cells increased post-transplant specifically in CMV+ recipients, and clonally expanded T cells were enriched for terminally differentiated cells post-transplant. Overall, these findings demonstrate a pattern of accelerated ag...Continue Reading

References

Nov 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·F G FergusonB Johansson
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N H SonN Weng
Jun 5, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Michael A Jarvis, Jay A Nelson
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Urs KarrerPaul Klenerman
Mar 30, 2005·The Journal of Experimental Medicine·Torsten BundeFlorian Kern
Jun 24, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anders WikbyBoo Johansson
Jul 1, 2008·Experimental Gerontology·Christian R GomezElizabeth J Kovacs
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niklas K BjörkströmHans-Gustaf Ljunggren
Jan 13, 2009·Clinical Microbiology Reviews·Tania Crough, Rajiv Khanna
Jun 23, 2009·Trends in Immunology·Nan-Ping WengJorg Goronzy
Feb 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pablo J E J van de BergRené A W van Lier
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Lan Wu, Luc Van Kaer
Apr 29, 2011·Kidney International·Michiel G H BetjesNicolle H R Litjens
Jan 10, 2012·Trends in Immunology·Geraldine A O'HaraRamon Arens
Jul 13, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Cécile CourivaudDidier Ducloux
Aug 25, 2012·Nature Reviews. Immunology·Stephen M HedrickErica L Stone
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C N Kotton
Feb 19, 2013·The Journal of Infectious Diseases·Cécile CourivaudDidier Ducloux
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R R RazonableUNKNOWN AST Infectious Diseases Community of Practice
Jan 13, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sofie Van GassenYvan Saeys
Mar 12, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T CrepinJ Bamoulid
Apr 4, 2015·Science Translational Medicine·David FurmanMark M Davis
Nov 14, 2015·Journal of the American Society of Nephrology : JASN·Matthew J BottomleyKathryn J Wood
Mar 31, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·T CrepinD Ducloux
Oct 11, 2016·Trends in Immunology·Arne N AkbarAlessio Lanna
Jan 7, 2017·Nature Medicine·Luca GattinoniChiara Bonini
Jan 14, 2017·Frontiers in Microbiology·Wenjuan Tu, Sudha Rao
Feb 16, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L E HigdonJ S Maltzman
May 4, 2017·Experimental Gerontology·Sara CantisánUNKNOWN Spanish Network for Research in Infectious Diseases (REIPI)
Aug 5, 2017·Frontiers in Immunology·Shahzma MeraniJanet E McElhaney
Dec 16, 2017·Nature Immunology·Janko Nikolich-Žugich
Mar 24, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Cecilia Martín-GandulUNKNOWN Spanish Network for Research in Infectious Diseases (REIPI)

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Citations

Sep 24, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lauren E HigdonJonathan S Maltzman

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Software Mentioned

Seurat
BDSMK
Lex
FlowJo
SeqGeq
UMAP
FlowSOM
VDJ Explorer
GraphPad Prism

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