Association of Preoperative Cell Counts With Outcomes After Operation for Congenital Heart Disease

The Annals of Thoracic Surgery
Shannon M JonesMatthew E Oster

Abstract

We examined the association of preoperative cell count abnormalities, which have been shown to be associated with outcomes in adult cardiac patients, with morbidity and mortality after operation for congenital heart disease (CHD) in children. We performed a retrospective cohort study on 4,865 children undergoing cardiac operation from 2004 to 2014. Our exposures of interest were presence of preoperative lymphopenia (lymphocyte count ≤ 3,000 cells/μL), thrombocytopenia (platelet count < 150 × 103/μL), and neutrophilia (neutrophil count ≥ 7,000 cells/μL). Our outcomes of interest were mortality status, postoperative length of stay (LOS), and occurrence of postoperative complications. We performed logistic and linear regressions to determine the associations of preoperative cell counts with mortality, LOS, and complications, adjusting for age, sex, race or ethnicity, presence of a genetic syndrome, and Society of Thoracic Surgeons and European Association for Cardio-Thoracic Surgery Congenital Heart Surgery Mortality category. Overall mortality was 2.8%, median LOS was 6 days, and 7.6% of patients had postoperative complications. Lymphopenia was associated with increased odds of postoperative mortality (odds ratio 1.67, 95% confid...Continue Reading

Citations

Mar 22, 2019·Anesthesia and Analgesia·Stephanie E JonesKelly A Machovec
Feb 23, 2019·General Thoracic and Cardiovascular Surgery·Omer Faruk SavlukHakan Ceyran
Oct 22, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Lucas Hoyos MejíaDavid Gómez de Antonio
May 18, 2021·Journal of the American Heart Association·Xie WuFuxia Yan
May 18, 2020·The Journal of Thoracic and Cardiovascular Surgery·Shu PengXiangning Fu

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