Association of Preoperative Opioid Use With Mortality and Short-term Safety Outcomes After Total Knee Replacement

JAMA Network Open
S C KimRishi J Desai

Abstract

Prescription opioid use is common among patients with moderate to severe knee osteoarthritis before undergoing total knee replacement (TKR). Preoperative opioid use may be associated with worse clinical and safety outcomes after TKR. To determine the association of preoperative opioid use among patients 65 years and older with mortality and other complications at 30 days post-TKR. This cohort study used claims data from January 1, 2010, to December 31, 2014, from a random sample of US Medicare enrollees 65 years and older who underwent TKR. Based on opioid dispensing in 360 days prior to TKR, patients were classified as continuous (≥1 opioid dispensing in each of the past 12 months) or intermittent (any dispensing of opioids in the past 12 months but not continuous use) opioid users or as opioid-naive patients (no opioids dispensed in the past 12 months). Data analyses were conducted from October 3, 2017, to November 8, 2018. Primary outcomes included in-hospital mortality and 30-day post-TKR mortality, hospital readmission, and revision operation. Secondary safety outcomes at 30 days post-TKR included opioid overdose and vertebral and nonvertebral fracture. Multivariable Cox proportional hazards models estimated hazard ratios ...Continue Reading

References

Jul 1, 1992·Journal of Clinical Epidemiology·W A RayM L Adams
Mar 10, 2007·Journal of Clinical Epidemiology·Sebastian SchneeweissDaniel H Solomon
Oct 11, 2007·The Journal of Arthroplasty·David A FisherKenneth Davis
Dec 15, 2010·Archives of Internal Medicine·Daniel H SolomonSebastian Schneeweiss
Jan 7, 2011·Journal of Clinical Epidemiology·Joshua J GagneSebastian Schneeweiss
Nov 4, 2011·The Journal of Bone and Joint Surgery. American Volume·Michael G ZywielMichael A Mont
Jan 25, 2012·Pharmacoepidemiology and Drug Safety·Natalie JonesMatthew W Reynolds
Feb 28, 2014·International Orthopaedics·Robert PivecMichael A Mont
Oct 21, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christopher RowePhillip O Coffin
Apr 24, 2017·Osteoarthritis and Cartilage·S C KimB T Bateman
Sep 21, 2017·The Journal of Arthroplasty·Katherine HadlandsmythBrian C Lund
Dec 16, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dae Hyun KimJerry Avorn
Jul 19, 2018·The Journal of Bone and Joint Surgery. American Volume·Jack WeickHue H Luu
Aug 9, 2018·JAMA : the Journal of the American Medical Association·Karim S LadhaBrian T Bateman

❮ Previous
Next ❯

Citations

Apr 7, 2020·The Journal of Bone and Joint Surgery. American Volume·Seoyoung C Kim, Brian T Bateman
Jan 1, 2020·Nature Reviews. Rheumatology·Seoyoung C Kim, Daniel H Solomon
Jun 21, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Patricia D FranklinDanielle C Lavallee
Aug 19, 2020·Current Rheumatology Reports·Cade ShadboltMichelle M Dowsey
Sep 9, 2020·The Journal of Knee Surgery·Darius HuntR Frank Henn
Aug 26, 2020·The Journal of Arthroplasty·Jeffrey B StamboughSimon C Mears
Feb 23, 2021·The Journal of Knee Surgery·William L SheppardAdam A Sassoon
Feb 17, 2021·The Journal of the American Academy of Orthopaedic Surgeons·Chukwuweike U GwamJohannes F Plate
May 11, 2020·Osteoarthritis and Cartilage·L K KingUNKNOWN BEST-Knee Team
Apr 9, 2021·Peptides·Richard J Bodnar
Apr 10, 2021·Clinical Orthopaedics and Related Research·Ahmed K EmaraNicolas S Piuzzi
May 4, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Henry MillerSteven Bonawitz
Jun 19, 2021·The Journal of Bone and Joint Surgery. American Volume·Patricia D FranklinDavid Cella
Jul 13, 2021·The Journal of Arthroplasty·Michael-Alexander MalahiasAlexander Greenberg

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.