Association of Preprocedural Hyperglycemia With Contrast-Induced Acute Kidney Injury and Poor Outcomes After Emergency Percutaneous Coronary Intervention

Angiology
Kaiyang LinChun-Jin Lin

Abstract

We investigated whether preprocedural hyperglycemia was associated with contrast-induced acute kidney injury (CI-AKI) and long-term outcomes in patients with acute coronary syndrome (ACS) who underwent emergency percutaneous coronary intervention (PCI). Patients (n = 558) with ACS who underwent emergency PCI were consecutively enrolled. Preprocedural hyperglycemia was defined as glucose levels >198 mg/dL (11 mmol/L). The primary outcome was CI-AKI (≥0.3 mg/dL absolute or ≥50% relative serum creatinine increase 48 hours after contrast medium exposure). Overall, 103 (18.5%) patients had preprocedural hyperglycemia and 89 (15.9%) patients developed CI-AKI. The incidence of CI-AKI was significantly higher in patients with hyperglycemia than without (28.2% vs 13.2%; P < .01). Multivariate analysis indicated that preprocedural hyperglycemia was an independent predictor of CI-AKI (odds ratio = 1.971, 95% confidence interval [CI]: 1.129-3.441; P < .05). In addition, preprocedural hyperglycemia was associated with an increased risk of all-cause mortality during the 2-year follow-up (hazard ratio = 2.440, 95% CI: 1.394-4.273; P = .002). Preprocedural hyperglycemia is a significant and independent predictor of CI-AKI and long-term outcomes.

References

Aug 10, 2001·Investigative Radiology·M WasakiK Shirota
Feb 19, 2002·Kidney International·Mark A CatherwoodElisabeth R Trimble
Feb 11, 2003·Critical Care Medicine·Greet Van den BerghePeter Lauwers
Feb 14, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan MelinBengt Fellström
Nov 3, 2004·Journal of the American College of Cardiology·Giancarlo MarenziAntonio L Bartorelli
Jun 8, 2006·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Kazuaki NishioTakashi Katagiri
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Sep 19, 2008·Critical Care : the Official Journal of the Critical Care Forum·Gisela Del Carmen De La RosaUNKNOWN Grupo de Investigacion en Cuidado intensivo: GICI-HPTU
Jun 23, 2009·The American Journal of Cardiology·Refat JabaraSteven V Manoukian
Jan 1, 2007·Journal of Medical Economics·Sujha SubramanianTeresa Zyczynski
Apr 3, 2010·Journal of the American College of Cardiology·Joshua M StolkerMikhail Kosiborod
Jun 23, 2010·AJR. American Journal of Roentgenology·David H O'DonnellMichael J Lee
Dec 15, 2010·American Heart Journal·Giancarlo MarenziAntonio L Bartorelli
Oct 6, 2011·Circulation. Cardiovascular Interventions·Mauro MaioliFrancesco Bellandi
Jan 24, 2012·European Heart Journal·Erdmann SeeligerPontus B Persson
May 11, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroyuki NaruseYukio Ozaki
Aug 28, 2012·European Heart Journal·UNKNOWN Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC)Doron Zahger
Apr 4, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Noriaki MoriyamaHisao Ogawa
Aug 2, 2014·Archives of Cardiovascular Diseases·Fabrice IvanesAnne Brunet-Bernard
Feb 12, 2015·BMC Anesthesiology·Amr S OmarRajvir Singh

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Citations

Jul 2, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Serhat SigirciKadriye O Kilickesmez
Mar 7, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Qing-Yong YangYan-Song Guo
Aug 29, 2019·Current Vascular Pharmacology·Kosmas I ParaskevasDemetrios V Vlahakos
Jun 18, 2021·Diabetology & Metabolic Syndrome·Sheila Marques Fernandes CoutoMaria de Fátima Fernandes Vattimo

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