Abstract
Early breast development is a risk factor for breast cancer, and girls with a breast cancer family history (BCFH) experience breast development earlier than girls without a BCFH. To assess whether prepubertal androgen concentrations are associated with timing of breast development (analysis 1) and to compare serum androgen concentrations in girls with and without a BCFH (analysis 2). Prospective cohort study of 104 girls aged 6 to 13 years at baseline using data collected between August 16, 2011, and March 24, 2016, from the Lessons in Epidemiology and Genetics of Adult Cancer From Youth (LEGACY) Girls Study, New York site. Analysis 1 included serum concentrations of dehydroepiandrosterone sulfate, androstenedione, and testosterone (free and total) measured before breast development and divided at the median into high and low categories. Analysis 2 included the degree of BCFH: first-degree was defined as having a mother with breast cancer and second-degree was defined as having a grandmother or aunt with breast cancer. Analysis 1 included age at onset of breast development measured using the Pubertal Development Scale (scores range from 1-4; scores ≥2 indicate breast development), and analysis 2 included serum androgen concentr...Continue Reading
References
May 1, 1979·Psychosomatic Medicine·M HorowitzW Alvarez
May 1, 1973·The Journal of Clinical Endocrinology and Metabolism·U GoebelsmannD R Mishell
May 2, 2000·Behavioral Medicine·S M VickbergW H Redd
Nov 26, 2003·Journal of Neuroendocrinology·R D Romeo
Sep 24, 2004·British Journal of Cancer·A C AntoniouD F Easton
Mar 3, 2010·Frontiers in Neuroendocrinology·Russell D Romeo
Apr 8, 2010·The Journal of Clinical Endocrinology and Metabolism·Thomas RemerStefan A Wudy
Apr 2, 2011·American Journal of Epidemiology·Rosenie Thelus JeanMichele R Forman
Apr 20, 2011·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Julianna DeardorffRobert A Hiatt
Jul 13, 2011·The Journal of Endocrinology·Allison R FoilbRussell D Romeo
Aug 5, 2011·Cancer Prevention Research·Rebecca E JamesRudolf Kaaks
Feb 28, 2013·JAMA : the Journal of the American Medical Association·Rebecca H JohnsonArchie Bleyer
Aug 15, 2013·British Journal of Cancer·R J MacInnisJ L Hopper
Oct 25, 2013·International Journal of Cancer. Journal International Du Cancer·Rudolf KaaksAnnekatrin Lukanova
Nov 6, 2013·Pediatrics·Frank M BiroMary S Wolff
Dec 18, 2013·Development and Psychopathology·Jenalee R Doom, Megan R Gunnar
Feb 6, 2014·Breast Cancer Research : BCR·Danielle H BodicoatAnthony J Swerdlow
Jul 17, 2014·The Journal of Clinical Endocrinology and Metabolism·Frank M BiroLorah D Dorn
Oct 14, 2014·PloS One·Lauren C HoughtonGillian R Bentley
Jan 4, 2015·Steroids·Susan B Brown, Susan E Hankinson
Apr 1, 2015·Journal of Psychosomatic Obstetrics and Gynaecology·Marni B JacobsEmily W Harville
Apr 29, 2015·Developmental Psychology·Jay BelskyMarilyn J Essex
Oct 21, 2015·Pediatrics·Angela R BradburyMary B Daly
Feb 2, 2016·Epidemiology·Esther M JohnIrene L Andrulis
Feb 24, 2017·Neurobiology of Stress·Cheryl M McCormickJonathan J Simone
Jun 10, 2017·Breast Cancer Research : BCR·Mary Beth TerryEsther M John