Association of pro-inflammatory soluble cytokine receptors early during hepatocellular carcinoma stereotactic radiotherapy with liver toxicity.

NPJ Precision Oncology
Sylvia S W NgLaura A Dawson

Abstract

Plasma levels of soluble factors early during hepatocellular carcinoma (HCC) stereotactic body radiotherapy (SBRT) were evaluated in relation to radiation liver injury, tumor response, and risk of early death. No significant differences were found in baseline plasma levels of AFP, CXCL1, and HGF amongst HCC patients with different Child Pugh scores. Higher levels of sTNFRII (P < 0.001), and lower levels of sCD40L (P < 0.001) and CXCL1 (P = 0.01) following one to two fractions of SBRT were noted in patients who developed liver toxicity vs. those who did not. High circulating levels of AFP (HR 2.16, P = 0.04), sTNFRII (HR 2.27, P = 0.01), and sIL-6R (HR 1.99, P = 0.03) early during SBRT were associated with increased risk of death 3 months post treatment. Plasma levels of the studied factors early during SBRT were not associated with tumor response. A pro-inflammatory systemic environment is associated with development of liver toxicity and increased risk of early death following SBRT.

References

May 31, 1990·European Journal of Biochemistry·S Rose-JohnP C Heinrich
Apr 23, 2003·The American Journal of Pathology·Sébastien Le JanStéphane Germain
May 17, 2003·Science·Monica Garcia-BarrosRichard Kolesnick
Sep 2, 2003·Nature Reviews. Immunology·Bharat B Aggarwal
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mario RoselliPatrizia Ferroni
Jan 1, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M G SciulliP Patrignani
May 12, 2006·World Journal of Gastroenterology : WJG·Maurizio SoresiGiuseppe Montalto
Jun 16, 2007·Gastroenterology·Hashem B El-Serag, K Lenhard Rudolph
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jan 2, 2010·Biochemical and Biophysical Research Communications·Biao LuKenneth R Feingold
Apr 30, 2010·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Alexandre Sampaio MouraManoel Otávio da Costa Rocha
Feb 8, 2011·Biochimica Et Biophysica Acta·Jürgen SchellerStefan Rose-John
Dec 14, 2011·Clinical & Developmental Immunology·Steven Eric FinkelsteinGeorge D Wilson
Apr 3, 2012·Expert Review of Proteomics·Charlotte GrootaertBarbara Vanhoecke
May 11, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christina HeemannDieter Kube
Oct 31, 2012·Digestive Diseases·Athena ChalarisStefan Rose-John
Apr 3, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexis BujoldLaura A Dawson
Feb 21, 2014·Seminars in Immunology·Koji Taniguchi, Michael Karin
Jun 8, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shaelyn CulletonLaura A Dawson
Jul 6, 2014·International Journal of Clinical Oncology·Chang W SongPaul W Sperduto
Jul 30, 2014·Gastroenterology·Fabio Marra, Frank Tacke
Dec 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip J JohnsonHidenori Toyoda
Oct 28, 2015·Journal of Experimental & Clinical Cancer Research : CR·Li LiJing Xu
Oct 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juri BergmannDirk Schmidt-Arras
Jul 5, 2017·Clinical Pharmacology and Therapeutics·Stefan Rose-John
Sep 4, 2017·Seminars in Radiation Oncology·Pablo Munoz-SchuffeneggerLaura A Dawson
Feb 6, 2018·International Journal of Radiation Oncology, Biology, Physics·Nitin OhriAndrew Jackson
May 12, 2019·Translational Oncology·Kyle C CuneoTheodore S Lawrence

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