PMID: 11606167Oct 19, 2001Paper

Association of proinsulin and insulin resistance with coronary artery disease in non-diabetic south Indian men

Diabetic Medicine : a Journal of the British Diabetic Association
C SnehalathaV Viswanathan

Abstract

To evaluate the association of plasma proinsulin and insulin resistance (IR) with coronary artery disease (CAD) in non-diabetic subjects. In this case control study, 41 normoglycaemic men with angiographic evidence of CAD were compared with 41 control men matched for age and glycaemia and with no history or evidence of cardiac diseases. Estimations of plasma glucose, lipids, fasting plasma specific insulin (SI) and proinsulin (PI) were performed. IR was calculated by the homeostasis model assessment (HOMA) method. Multiple logistic regression analysis was performed to test the association of the variables with the prevalence of CAD. Subjects with CAD had a higher body mass index (BMI) (25.4 +/- 4.3 vs. 22.9 +/- 3.2 kg/m2, P = 0.003) and waist to hip ratio (WHR) (0.95 +/- 0.05 vs. 0.89 +/- 0.09, P = 0.001) and a lower high-density lipoprotein (HDL) cholesterol level (0.97 +/- 0.2 vs. 1.1 +/- 0.2 mmol/l, P = 0.002). They also had higher mean SI values (107.5 vs. 62.3 pmol/l, P = 0.002), PI values (19.3 vs. 5.7 pmol/l, P < 0.0001), PI/SI ratios (21.4 vs. 10.3, P < 0.0001) and HOMA IR (4.2 vs. 2.4, P = 0.004) compared with non-CAD subjects. These variables were associated with CAD in the unadjusted multiple regression analysis. In ...Continue Reading

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Citations

May 8, 2002·Diabetes/metabolism Research and Reviews
Feb 24, 2006·Cardiology in Review·Updesh Singh BediRohit Arora
Feb 28, 2008·Der Internist·B StratmannD Tschoepe
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Seyed Amir MirbagheriMehdi Abouzari
Jul 12, 2005·Diabetes Research and Clinical Practice·C SnehalathaA Ramachandran
Dec 1, 2012·Global Heart·Manisha Nair, Dorairaj Prabhakaran
Sep 28, 2005·Diabetes Care·Ambady RamachandranTuomilehto Jaakko
Sep 11, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A DasV L Murthy
Aug 6, 2004·Endocrine Reviews·Zhi You FangThomas H Marwick

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