Association of Psychiatric Comorbidity With the Risk of Premature Death Among Children and Adults With Attention-Deficit/Hyperactivity Disorder

JAMA Psychiatry
Shihua SunHenrik Larsson

Abstract

A previous register-based study reported elevated all-cause mortality in attention-deficit/hyperactivity disorder (ADHD), but cause-specific risks and the potential associations of psychiatric comorbidities remain unknown. To investigate the all-cause and cause-specific mortality risks in ADHD and to explore the potential role of psychiatric comorbidities. This prospective cohort study used Swedish national registers to identify 2 675 615 individuals born in Sweden from January 1, 1983, through December 31, 2009, as the study population, among whom 86 670 individuals (3.2%) received a diagnosis of ADHD during follow-up. Follow-up was completed December 31, 2013, and data were analyzed from October 2018 through March 2019. Attention-deficit/hyperactivity disorder identified by first clinical diagnosis or first prescription of ADHD medications as recorded in Swedish registers. Clinical diagnosis of psychiatric comorbidity was available in the National Patient Register. All-cause and cause-specific mortalities and hazard ratios (HRs) using Cox proportional hazards regression models. In the overall cohort of 2 675 615 individuals, 1 374 790 (51.4%) were male (57 919 with an ADHD diagnosis) and 1 300 825 (48.6%) were female (28 751 ...Continue Reading

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Citations

Jan 3, 2020·JAMA Psychiatry·Charles F Zorumski
Apr 25, 2020·International Journal of Environmental Research and Public Health·Giancarlo GiupponiMaurizio Pompili
Nov 21, 2020·Scandinavian Journal of Psychology·Elin NylanderMikael Landén
Dec 10, 2020·JAMA Psychiatry·Marica LeoneSarah E Bergen
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Sep 10, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Le ZhangZheng Chang

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