Association of pulmonary, cardiovascular, and hematologic metrics with carbon nanotube and nanofiber exposure among U.S. workers: a cross-sectional study

Particle and Fibre Toxicology
Mary K Schubauer-BeriganMarie A de Perio

Abstract

Commercial use of carbon nanotubes and nanofibers (CNT/F) in composites and electronics is increasing; however, little is known about health effects among workers. We conducted a cross-sectional study among 108 workers at 12 U.S. CNT/F facilities. We evaluated chest symptoms or respiratory allergies since starting work with CNT/F, lung function, resting blood pressure (BP), resting heart rate (RHR), and complete blood count (CBC) components. We conducted multi-day, full-shift sampling to measure background-corrected elemental carbon (EC) and CNT/F structure count concentrations, and collected induced sputum to measure CNT/F in the respiratory tract. We measured (nonspecific) fine and ultrafine particulate matter mass and count concentrations. Concurrently, we conducted physical examinations, BP measurement, and spirometry, and collected whole blood. We evaluated associations between exposures and health measures, adjusting for confounders related to lifestyle and other occupational exposures. CNT/F air concentrations were generally low, while 18% of participants had evidence of CNT/F in sputum. Respiratory allergy development was positively associated with inhalable EC (p=0.040) and number of years worked with CNT/F (p=0.008). ...Continue Reading

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Citations

Feb 5, 2019·Annals of Work Exposures and Health·Matthew M DahmMary K Schubauer-Berigan
Dec 11, 2019·Environmental Health : a Global Access Science Source·Wei-Te WuSaou-Hsing Liou
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Apr 4, 2021·Cancers·Marcella Barbarino, Antonio Giordano
Apr 4, 2021·Nanomaterials·Enrico BergamaschiIrina Guseva Canu

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Methods Mentioned

BETA
transmission electron microscopy

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