Abstract
Commercial use of carbon nanotubes and nanofibers (CNT/F) in composites and electronics is increasing; however, little is known about health effects among workers. We conducted a cross-sectional study among 108 workers at 12 U.S. CNT/F facilities. We evaluated chest symptoms or respiratory allergies since starting work with CNT/F, lung function, resting blood pressure (BP), resting heart rate (RHR), and complete blood count (CBC) components. We conducted multi-day, full-shift sampling to measure background-corrected elemental carbon (EC) and CNT/F structure count concentrations, and collected induced sputum to measure CNT/F in the respiratory tract. We measured (nonspecific) fine and ultrafine particulate matter mass and count concentrations. Concurrently, we conducted physical examinations, BP measurement, and spirometry, and collected whole blood. We evaluated associations between exposures and health measures, adjusting for confounders related to lifestyle and other occupational exposures. CNT/F air concentrations were generally low, while 18% of participants had evidence of CNT/F in sputum. Respiratory allergy development was positively associated with inhalable EC (p=0.040) and number of years worked with CNT/F (p=0.008). ...Continue Reading
References
Nov 24, 1999·American Journal of Epidemiology·A PetersH E Wichmann
Feb 23, 2005·Occupational and Environmental Medicine·J Y KimD C Christiani
Mar 16, 2005·Lancet·Anthony Seaton, Kenneth Donaldson
Jul 5, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Mar 2, 2006·Environmental Health Perspectives·Timothy R NurkiewiczMatthew A Boegehold
Dec 4, 2008·Nano Letters·Aaron ErdelyPetia P Simeonova
Jun 30, 2009·Inhalation Toxicology·Petia P Simeonova, Aaron Erdely
Jul 8, 2009·Nature Nanotechnology·L A MitchellJ D McDonald
Jul 22, 2009·Hypertension·Robert D BrookJeffrey R Brook
Sep 24, 2009·Environmental and Molecular Mutagenesis·L M SargentS H Reynolds
May 27, 2010·JAMA : the Journal of the American Medical Association·Brent M EganR Neal Axon
Jun 17, 2011·Journal of Occupational and Environmental Medicine·Mary K Schubauer-BeriganMarianne S Yencken
Jun 17, 2011·Journal of Occupational and Environmental Medicine·A Scott LaneyMary K Schubauer-Berigan
Jul 26, 2011·Particle and Fibre Toxicology·Robert R MercerDale W Porter
Apr 19, 2013·Heart·Magnus Thorsten JensenFinn Gyntelberg
Oct 11, 2013·Respiratory Research·Timothy TilertBrent Doney
Feb 5, 2014·Industrial Health·Hui-Yi LiaoSaou-Hsing Liou
Nov 15, 2014·Nanotoxicology·Jong Seong LeeIl Je Yu
Dec 17, 2014·Environmental Health : a Global Access Science Source·Yulia OlsenSteffen Loft
Jan 13, 2015·Chemical Research in Toxicology·Rui ChenChunying Chen
Apr 9, 2015·The Annals of Occupational Hygiene·Matthew M DahmJames A Deddens
Sep 13, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Günter OberdörsterPhil Sayre
May 25, 2016·Archives of Toxicology·Monita SharmaAmy J Clippinger
Aug 12, 2016·MMWR. Morbidity and Mortality Weekly Report·Taylor M ShockeyErika C Odom
Oct 16, 2016·Particle and Fibre Toxicology·Tatsuya KasaiShoji Fukushima
Feb 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Mario J AragonMatthew J Campen
Mar 17, 2017·Nanotoxicology·Jelle VlaanderenRoel Vermeulen
Aug 2, 2017·ACS Nano·Lindsey BishopAaron Erdely
Jan 18, 2018·International Journal of Hygiene and Environmental Health·Matthew M DahmSergey A Grinshpun
Apr 27, 2018·Environment International·John D BeardMary K Schubauer-Berigan
Citations
Feb 5, 2019·Annals of Work Exposures and Health·Matthew M DahmMary K Schubauer-Berigan
Feb 8, 2020·Nanotoxicology·Mary K Schubauer-BeriganAaron Erdely
Apr 28, 2020·Small·Sijin Liu, Tian Xia
Aug 14, 2018·Indoor Air·Aleksandr B StefaniakDuane Hammond
Dec 11, 2019·Environmental Health : a Global Access Science Source·Wei-Te WuSaou-Hsing Liou
Nov 27, 2019·Sensors·Rodolfo Rocha Vieira LeocádioCibelle Ferreira Louzada
Dec 4, 2019·Journal of Biological Engineering·Junhyoung ByunTae Hoon Kim
Oct 21, 2020·Journal of Applied Toxicology : JAT·Yishuo GuTao Li
Dec 9, 2020·Particle and Fibre Toxicology·Kelly FraserAaron Erdely
Feb 11, 2021·Cell Reports·Satoshi OmoriMasafumi Nakayama
Apr 4, 2021·Cancers·Marcella Barbarino, Antonio Giordano
Apr 4, 2021·Nanomaterials·Enrico BergamaschiIrina Guseva Canu
Apr 11, 2021·Journal of Applied Toxicology : JAT·Yi Cao
Jan 18, 2022·Inhalation Toxicology·Tamara L YoungMatthew J Campen