Association of pyrethroids exposure with onset of puberty in Chinese girls

Environmental Pollution
Xiaoqing YeJing Liu

Abstract

Pyrethroids, a class of ubiquitous insecticides, have been considered as endocrine-disrupting chemicals (EDCs). Female animal studies suggested that early-life pyrethroids exposure might delay puberty onset. However, it remains unclear whether this association applies to human populations. A total of 305 girls at the ages of 9-15 years old were recruited in Hangzhou, China in this study. The concentration of the common metabolite of pyrethroids, 3-phenoxybenzoic acid (3-PBA), was analyzed in urine samples to reflect the exposure level of pyrethroids. The associations of 3-PBA with pubertal stages were evaluated using a multinomial logistic regression model. The geometric mean level of 3-PBA was 1.11 μg/L (1.42 μg/g for creatinine-adjusted concentration). There was a significant 45% reduction in odds of being in breast stage 3 (B3) per one-unit increase in the log-transformed 3-PBA levels [OR = 0.55 (95%CI: 0.31-0.98), p = 0.042]. A similar negative association was found between urinary 3-PBA levels with later onset by pubic hair stage 2 (P2) [OR = 0.56 (95%CI: 0.36-0.90), p = 0.015]. Similar negative association was also observed between urinary 3-PBA levels and pubertal onset indicated by menarche [OR = 0.51 (95%CI: 0.28-0.93)...Continue Reading

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Citations

Nov 15, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Louise C Greenspan, Mary M Lee
Nov 18, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Feixue LiJing Liu
Jul 2, 2019·Annals of Pediatric Endocrinology & Metabolism·Jeong Eun LeeYoung Ah Lee
Jan 5, 2021·Environmental Science and Pollution Research International·Toshiaki YoshidaNaomi Sakon
Jan 21, 2021·Environmental Science and Pollution Research International·Eloisa Lovison SassoBarbara Clasen
Dec 1, 2019·Environment International·Alba Iglesias-GonzálezBrice M R Appenzeller
Jul 3, 2021·International Journal of Environmental Research and Public Health·Aleksandra FucicJohn E Vena
Jul 31, 2021·The Science of the Total Environment·Xuan LinJing Liu
Feb 16, 2018·Environmental Science & Technology·Chunming LiJianhong Zhou
Nov 28, 2021·Nutrients·Anastasia Konstantina SakaliMaria Papagianni

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