Association of Radioactive Iodine Administration After Reoperation With Outcomes Among Patients With Recurrent or Persistent Papillary Thyroid Cancer.

JAMA Surgery
Matthew L HungMichael W Yeh

Abstract

One-third of patients with papillary thyroid cancer (PTC) develop persistent or recurrent disease after initial therapy. Most patients with persistent or recurrent disease undergo reoperation, but the role of treatment with radioactive iodine (RAI) after reoperation is unclear. To determine whether receipt of RAI after reoperation for recurrent PTC is associated with improved outcomes. This retrospective cohort study included electronic health record data from 102 patients who underwent neck reoperation for persistent or recurrent PTC at a tertiary referral center from April 2006 to January 2016; 50 patients received RAI after reoperation, and 52 did not receive RAI after reoperation. Data analysis was performed from September 1, 2017, to December 1, 2017. Suppressed thyroglobulin (Tg) levels were compared between patients who underwent reoperation and received RAI and patients who underwent reoperation without receipt of RAI at the following time points: before reoperation (Tg0), after reoperation (Tg1), and after RAI or a comparable time interval among patients whose cases were managed without RAI (Tg2). Outcomes were biochemical response and structural recurrence after reoperation. The cohort comprised 102 patients who under...Continue Reading

References

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Dec 15, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Arnoldo PiccardoLuca Giovanella

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Citations

Jan 19, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I J NixonA Ferlito
Nov 24, 2021·JAMA : the Journal of the American Medical Association·Alexander T Hawkins, Lauren R Samuels

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