Association of recurrent cerebral infarction with adenosine diphosphate- and collagen-induced platelet aggregation in patients treated with ticlopidine and/or aspirin

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Takeo Abumiya, Kiyohiro Houkin

Abstract

Although the platelet aggregation test is the most common method for evaluating response to antiplatelet therapy, little is known about the association of recurrent cerebral infarction with platelet aggregation in the presence of various different antiplatelet drugs. We prospectively evaluated adenosine diphosphate (ADP)- and collagen-induced platelet aggregation and followed the incidence of recurrent infarction in patients categorized into 3 groups based on treatment; aspirin (n = 144), ticlopidine (n = 100), and aspirin + ticlopidine (n = 96). The patients in each treatment group were stratified into quartiles according to platelet aggregation, and the association of recurrent infarction with platelet aggregation was investigated. ADP-induced platelet aggregation values were significantly lower in the ticlopidine group and the aspirin + ticlopidine group compared with the aspirin group (P < .001), and collagen-induced platelet aggregation values were significantly lower in the aspirin group and the aspirin + ticlopidine group compared with the ticlopidine group (P < .001). In the aspirin group, the recurrence rate was somewhat higher in the higher aggregation quartiles than in the lower aggregation quartiles of 2 μg/mL colla...Continue Reading

References

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Nov 25, 2003·Stroke; a Journal of Cerebral Circulation·Masako Yamazaki, Shinichiro Uchiyama
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Jan 19, 2008·BMJ : British Medical Journal·George KrasopoulosMichael R Buchanan
Mar 3, 2009·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Friederike von LewinskiWalter Paulus

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