Association of regional white matter hyperintensity volumes with cognitive dysfunction and vascular risk factors in patients with amnestic mild cognitive impairment.

Geriatrics & Gerontology International
Kentaro HiraoSoichiro Shimizu

Abstract

White matter hyperintensities (WMH) obtained by magnetic resonance imaging (MRI) have been reported to promote neurodegeneration and cognitive decline in patients with mild cognitive impairment (MCI). However, little is known about the association between regional WMH (rWMH) and cognitive dysfunction in MCI. We hence investigated the associations between rWMH volumes and cognitive dysfunction in MCI. Thirty-eight subjects with amnestic MCI were analysed. The volumes of periventricular hyperintensities (PVH) and deep WMH (DWMH) were measured on a T2-FLAIR MRI using a 3D-slicer, and regional PVH and DWMH (rPVH and rDWMH) volumes were calculated. The associations of rPVH and rDWMH volumes with cognition and blood levels of various molecules were investigated. Furthermore, rPVH and rDWMH volumes were compared between MCI with vascular risk factors, such as hypertension, diabetes mellitus (DM), and dyslipidemia, and those without these risk factors. rPVH volume (bilateral cornu frontale, pars parietalis, and cornu occipitale) positively correlated with Trail Making Test-A/B scores and CysC level, whereas rDWMH volume did not correlate with any of the items. rPVH volumes (right cornu frontale, bilateral pars parietalis and cornu occi...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Feb 24, 2001·Journal of Neuropathology and Experimental Neurology·E LevyF Tagliavini
Dec 20, 2005·Lancet Neurology·Geert Jan BiesselsPhilip Scheltens
Mar 29, 2006·Diabetes·Sanne M ManschotUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Apr 22, 2006·Stroke; a Journal of Cerebral Circulation·Malee S FernandoUNKNOWN MRC Cognitive Function and Ageing Neuropathology Study Group
May 12, 2007·Diabetologia·C JongenUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Feb 12, 2008·Acta Neurologica Scandinavica·N UmegaeS Yamaguchi
Oct 1, 2008·Journal of Neurology·Elisabeth C W van StraatenUNKNOWN Alzheimer's Disease Cooperative Study Group
Nov 20, 2009·Neurobiology of Aging·Tomohiko SatoToshihiko Iwamoto
Feb 5, 2011·Diabetes/metabolism Research and Reviews·Yael D ReijmerUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Dec 4, 2012·Brain : a Journal of Neurology·Mark YarchoanSteven E Arnold
Nov 10, 2013·Neurobiology of Aging·Alex C BirdsillBarbara B Bendlin
Oct 1, 2015·Acta Neuropathologica Communications·Kirsty E McAleeseJohannes Attems
Dec 17, 2015·Geriatrics & Gerontology International·Leonardo PantoniUNKNOWN LADIS Study Group
Oct 25, 2017·The Journal of Experimental Medicine·Axel MontagneBerislav V Zlokovic
Jan 22, 2019·Geriatrics & Gerontology International·Yusuke OgawaHaruo Hanyu
Aug 20, 2019·Diabetologia·Geert J Biessels, Rachel A Whitmer
Sep 7, 2019·Geriatrics & Gerontology International·Kentaro HiraoHaruo Hanyu
Nov 7, 2019·Journal of Clinical Medicine·Kaechang ParkMakoto Sasaki
Dec 4, 2019·Neurobiology of Aging·Katherine J BangenUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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