Association of regions on chromosomes 6 and 7 with blood pressure in Nigerian families.

Circulation. Cardiovascular Genetics
Bamidele O TayoRichard S Cooper

Abstract

Elevated blood pressure (BP) shares a level of heritability similar to many other traits related to cardiovascular risk; however, specific susceptibility loci have been difficult to localize. We conducted a multistage study of BP as a continuous trait in a low-risk West African population in which it was anticipated that environmental exposures would be reduced in complexity and intensity. In our earlier genome-wide linkage study for BP in this population, strong linkage evidence was noted on chromosomes 6 and 7. We subsequently genotyped a total of 3431 tag single-nucleotide polymorphisms (SNPs) in 3 regions (viz, 152.68 to 165.99 Mb on chromosome 6, 0.29 to 20.67 Mb, and 104.09 to 123.06 Mb on chromosome 7) in 713 individuals from 199 families. We conducted a family-based association analysis using individual SNPs and associated haplotypes. After correction for multiple comparisons, 6 intronic and 1 intergenic SNPs achieved nominal statistical significance (P<0.05) for the association with BP. The associated intronic SNPs include 2 in the PARK2 gene on chromosome 6; 2 in the KCND2 gene, and 1 each in the C7orf58 and HDAC9 genes on chromosome 7. The intergenic SNP is located between the RPA3 and GLCCI1 genes on chromosome 7. T...Continue Reading

References

Mar 1, 1983·American Journal of Medical Genetics·K Lange, M Boehnke
Oct 1, 1982·Annals of Human Genetics·J L Hopper, J D Mathews
Feb 1, 1997·American Journal of Public Health·R CooperR Wilks
Jan 23, 1999·American Journal of Human Genetics·D W FulkerJ K Hewitt
Feb 19, 1999·Lancet·D M Lloyd-JonesD Levy
Jan 13, 2000·American Journal of Human Genetics·G R AbecasisW O Cookson
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
May 16, 2002·Journal of Hypertension·Adebowale A AdeyemoRichard S Cooper
Jul 18, 2002·Cardiology Clinics·Richard S Cooper, Ramon Durazo-Arvizu
Jul 11, 2003·Nature·Ladeana W HillierRichard K Wilson
Sep 11, 2003·Annals of Internal Medicine·Richard S Cooper
Jan 21, 2004·Hypertension·Ruth Ann BarkleyUNKNOWN Family Blood Pressure Program
Apr 27, 2004·Journal of Hypertension·Patricia M KearneyJiang He
Jun 3, 2004·Current Opinion in Genetics & Development·John Blangero
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jan 25, 2005·Nature Genetics·Xiaofeng ZhuAlan Weder
Jun 9, 2005·Journal of Hypertension·Adebowale AdeyemoXiaofeng Zhu
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler
Apr 28, 2007·Science·UNKNOWN Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical RShaun Purcell
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Jun 15, 2007·PLoS Genetics·Markus PerolaUNKNOWN GenomEUtwin Project
Oct 10, 2007·American Journal of Human Genetics·Wei-Min Chen, Goncalo R Abecasis
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart
Jan 15, 2008·Nature Genetics·Serena SannaKaren L Mohlke
Feb 13, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Loïc Le Marchand, Lynne R Wilkens
Jun 24, 2008·Nature Genetics·Tushar R BhangaleDeborah A Nickerson

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Citations

Aug 8, 2012·Hypertension·Michael J FlisterHoward J Jacob
Nov 26, 2013·Progress in Cardiovascular Diseases·Fasil Tekola-AyeleCharles N Rotimi
Jun 4, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hyun-Seok JinSeon-Yong Jeong
Jun 6, 2018·Molecular Genetics & Genomic Medicine·Adebowale A AdeyemoOlayemi O Omotade
Jul 9, 2014·Hypertension·Sasha Z PriscoJozef Lazar
Oct 17, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Sasha Z PriscoJozef Lazar
Sep 29, 2020·Frontiers in Molecular Neuroscience·Masahito Yamagata
Apr 9, 2021·Frontiers in Cell and Developmental Biology·Kai-Lieh LinTsu-Kung Lin

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