Abstract
Patients with aortic valve sclerosis (AVS) have an increased risk of cardiovascular events. Patients with atherosclerotic renal artery stenosis (RAS) develop resistant hypertension and heart failure. We hypothesized AVS may be copresent with RAS in hypertensive patients. Hypertensive patients with AVS (n = 167) underwent magnetic resonance (MR) angiography using nonenhanced steady-state free precession (SSFP) technique. More than 75% luminal narrowing in the proximal region of main renal artery was regarded as significant RAS. Peak aortic jet velocity was obtained by Doppler echocardiography. We measured brain natriuretic peptide (BNP), and estimated glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease equation. Unilateral or bilateral RAS was detected in 40 patients. AVS patients with RAS were older (78 +/- 6 vs. 74 +/- 8 years), and had higher levels of aortic jet velocity (162 +/- 4 vs. 144 +/- 3 cm/s), and lower levels of GFR (55 +/- 13 vs. 62 +/- 14 ml/min/1.73 m(2)) than those without RAS. Higher aortic jet velocity (odds ratio (OR) = 1.58, 95% confidence interval (CI) = 1.09-2.31) and lower GFR (OR = 0.54, 95% CI = 0.33-0.38) were associated with the presence of RAS, after being adjusted for a...Continue Reading
References
Oct 1, 1996·The American Journal of Cardiology·G de SimoneB V Howard
Nov 4, 1998·Lancet·P MacDowallK Brown
Jul 15, 1999·The New England Journal of Medicine·C M OttoD S Siscovick
Oct 17, 2001·Circulation·K PohleS Achenbach
Mar 3, 2004·Radiology·Kenneth L CoenegrachtsGuy J Marchal
May 4, 2004·Journal of the American College of Cardiology·Christopher E BullerAdeera Levin
Sep 18, 2004·The American Journal of Cardiology·Harmony R ReynoldsItzhak Kronzon
Dec 28, 2004·The American Journal of Cardiology·Michael H OlsenUNKNOWN LIFE substudy
Apr 27, 2005·Archives of Internal Medicine·Kevin D O'BrienMatthew J Budoff
Jun 22, 2005·Circulation·Rosario V Freeman, Catherine M Otto
Sep 1, 2005·Circulation·Vesna D Garovic, Stephen C Textor
Dec 27, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangUNKNOWN European Association of Echocardiography
May 20, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Kevin D O'Brien
Jun 10, 2006·Journal of the American Society of Nephrology : JASN·Kwok-Wai MuiArend-Jan Woittiez
Aug 18, 2006·Journal of Hypertension·Cristiano FavaAlberto Morganti
Mar 6, 2007·Journal of the American College of Cardiology·Mathew S MaurerDalane W Kitzman
Jul 17, 2007·The American Journal of Cardiology·Ramesh de SilvaJohn G F Cleland
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Michel Chonchol, Stuart Linas
Oct 10, 2007·Hypertension·Daniel G HackamStephen C Textor
Apr 15, 2009·Journal of Hypertension·Quirijn de Mast, Jaap J Beutler
May 26, 2009·The American Journal of Cardiology·Francesco Antonini-CanterinUNKNOWN Research Group of the Italian Society of Cardiovascular Echography (SIEC)