Association of renin-angiotensin system genes polymorphisms and risk of premature ST elevation myocardial infarction in young Mexican population

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Irma Isordia-SalasAbraham Majluf-Cruz

Abstract

: The renin-angiotensin system plays an important role in the regulation of blood pressure and the development of coronary artery disease. The aim was to examine the association of the insertion deletion in the angiotensin-converting enzyme gene, M235T and T174M polymorphisms in the angiotensinogen gene with ST elevation acute myocardial infarction (STEAMI) in young Mexican population. We analyzed 242 unrelated patients with STEAMI 45 or less years of age, admitted to a cardiovascular intense care unit, and 242 individuals without STEAMI matched by age and sex, recruited from January 2006 and June 2013. The polymorphisms insertion deletion, M235T and T174M were determined in all participants by a polymerase chain-reaction-restriction fragment length polymorphism assay. There was a significant difference in the insertion deletion genotype distribution between two groups (P = 0.03) and a higher percentage of the T allele M235T polymorphism in the group of STEAMI patients (P = 0.02). The T174M polymorphism was not associated (P = 0.08). The insertion deletion and M235T polymorphisms, smoking, hypertension, familial history of cardiovascular disease and dyslipidemia were independent risk factors for STEAMI. Our results identified t...Continue Reading

References

Feb 7, 2003·Current Pharmaceutical Design·Rajko Igić, Rahim Behnia
Jun 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Amar Akhtar SethiAnne Tybjaerg-Hansen
Aug 10, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Cevad SekuriMustafa Akin
Jan 20, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Irma Isordia-SalasGabriela Borrayo-Sánchez
Jul 20, 2010·Archives of Medical Research·Irma Isordia-SalasAbraham Majluf-Cruz
Jul 27, 2010·Clinical Biochemistry·Asad Vaisi-RayganiTayebeh Pourmotabbed
Dec 15, 2010·Journal of Clinical Pharmacology·Bettina A HamelinJacques Turgeon
Dec 14, 2011·Clinical and Experimental Hypertension : CHE·Vamsi U MohanaTirunilai Padma
Apr 3, 2012·Journal of Thrombosis and Thrombolysis·David Santiago-GermánIrma Isordia-Salas
Jul 14, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Xingsheng LiZhigang Wang
Jan 7, 2014·Genetics and Molecular Research : GMR·A I GuneyM Agirbasli
May 27, 2014·BioMed Research International·Kh Dhanachandra SinghMuthusamy Karthikeyan
Dec 1, 2013·Global Heart·Fernando LanasAlejandra Lanas
Mar 15, 2015·Circulation Research·Luuk Te RietA H Jan Danser
May 7, 2015·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tao GaoYongjie Bai
May 13, 2015·Genetics and Molecular Research : GMR·P Y HuH W Wang
May 20, 2015·Journal of Biological Research·Amal Al-HazzaniAbdulaziz A Al-Jafari
Feb 4, 2016·World Journal of Cardiology·Xuming DaiMarschall S Runge

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Juan Carlos Esparza-GarcíaIrma Isordia-Salas
Revista da Associação Médica Brasileira
Messias Antônio AraújoLuiz Ricardo Goulart
© 2022 Meta ULC. All rights reserved