Association of rodent-borne Leptospira spp. with urban environments in Malaysian Borneo

PLoS Neglected Tropical Diseases
Kim R BlasdellCadhla Firth

Abstract

Although leptospirosis is traditionally considered a disease of rural, agricultural and flooded environments, Leptospira spp. are found in a range of habitats and infect numerous host species, with rodents among the most significant reservoirs and vectors. To explore the local ecology of Leptospira spp. in a city experiencing rapid urbanization, we assessed Leptospira prevalence in rodents from three locations in Malaysian Borneo with differing levels of anthropogenic influence: 1) high but stable influence (urban); 2) moderate yet increasing (developing); and 3) low (rural). A total of 116 urban, 122 developing and 78 rural rodents were sampled, with the majority of individuals assigned to either the Rattus rattus lineage R3 (n = 165) or Sundamys muelleri (n = 100). Leptospira spp. DNA was detected in 31.6% of all rodents, with more urban rodents positive (44.8%), than developing (32.0%) or rural rodents (28.1%), and these differences were statistically significant. The majority of positive samples were identified by sequence comparison to belong to known human pathogens L. interrogans (n = 57) and L. borgpetersenii (n = 38). Statistical analyses revealed that both Leptospira species occurred more commonly at sites with higher...Continue Reading

References

Sep 1, 1992·Journal of Clinical Microbiology·F MérienI Saint Girons
May 1, 1992·Journal of Clinical Pathology·B S HoS I Egglestone
Jan 1, 1988·Veterinary Research Communications·A R Bahaman, A L Ibrahim
Aug 31, 2002·The American Journal of Tropical Medicine and Hygiene·Urmimala SarkarAlbert I Ko
Dec 4, 2003·The Lancet Infectious Diseases·Ajay R BhartiUNKNOWN Peru-United States Leptospirosis Consortium
Sep 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dieter M BulachBen Adler
Sep 19, 2006·FEMS Microbiology Letters·Bernard La ScolaDidier Raoult
Dec 23, 2006·Indian Journal of Medical Microbiology·R N SwapnaJ Sudarsana
Apr 24, 2008·PLoS Neglected Tropical Diseases·Renato B ReisAlbert I Ko
Apr 28, 2009·Epidemiology and Infection·L H KrøjgaardA-C Heiberg
Sep 8, 2009·BMC Infectious Diseases·Ann Florence B VictorianoBen Adler
May 4, 2010·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Kalimuthusamy NatarajaseenivasanSubhash Chandra Sehgal
May 5, 2010·The American Journal of Tropical Medicine and Hygiene·Sharon Y A M VillanuevaShin-ichi Yoshida
Jun 4, 2010·The American Journal of Tropical Medicine and Hygiene·Emily A KendallW Abdullah Brooks
Nov 1, 2011·PLoS Neglected Tropical Diseases·Julie PerezCyrille Goarant
Jun 6, 2012·The American Journal of Tropical Medicine and Hygiene·Svilena IvanovaSerge Morand
Jan 3, 2013·Molecular Ecology·Marie PagèsJean-François Cosson
Jan 30, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·A A Noor RafizahI Zaliha
Mar 22, 2013·PLoS Neglected Tropical Diseases·Pascale BourhyMathieu Picardeau
Jul 3, 2013·PLoS Neglected Tropical Diseases·Chelsea G HimsworthDavid M Patrick
Aug 24, 2013·Emerging Infectious Diseases·Chien-Chin HsuW Ian Lipkin
Nov 16, 2013·Science·M C HansenJ R G Townshend
Jun 6, 2014·PLoS Neglected Tropical Diseases·Jean-François CossonSerge Morand
Jan 30, 2015·Vector Borne and Zoonotic Diseases·Hoang Kim LoanJuan J Carrique-Mas
Sep 18, 2015·PLoS Neglected Tropical Diseases·Mwanajaa Abdalla MwachuiJan Hattendorf
Sep 18, 2015·PLoS Neglected Tropical Diseases·Federico CostaAlbert I Ko
Oct 6, 2015·PLoS Neglected Tropical Diseases·Gauthier DobignyEric Bertherat
Dec 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Daniel R Richards, Daniel A Friess
Apr 6, 2016·Asia-Pacific Journal of Public Health·Douadi BenacerSiti Nursheena Mohd Zain
May 18, 2016·Journal of Wildlife Diseases·Emilie U Andersen-RanbergPer M Jensen
Jun 17, 2016·Journal of Evolutionary Biology·S GryseelsS J E Baird
Jul 15, 2016·Osong Public Health and Research Perspectives·J Mohd RidzuanW M Zahiruddin
Mar 30, 2017·Journal of Tropical Medicine·Chai Fung PuiLela Su'ut
Jun 15, 2017·Cadernos de saúde pública·Kevin Escandón-VargasMiryam Astudillo-Hernández
Jun 21, 2017·EcoHealth·Jamie L RothenburgerClaire M Jardine

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Citations

Aug 10, 2019·PLoS Neglected Tropical Diseases·Kenneth BoeySreekumari Rajeev
Jun 4, 2019·BMJ Case Reports·Afroditi RoumpouChristos Lampropoulos
Aug 6, 2020·Antibiotics·Fabrizio BertelloniFilippo Fratini
Jul 19, 2020·Pathogens·Giovanni CiliaFilippo Fratini
Jun 20, 2020·Veterinary Medicine and Science·Giovanni CiliaFilippo Fratini
Jan 21, 2021·Animals : an Open Access Journal From MDPI·Giovanni CiliaFilippo Fratini
Feb 5, 2021·Pathogens·Antony V SamrotPooi Ling Mok
Mar 28, 2020·Parasite Epidemiology and Control·Azar ShokriSeyed Ahmad Hashemi
Mar 26, 2020·Comparative Immunology, Microbiology and Infectious Diseases·Francesca CoppolaAntonio Felicioli
Jun 22, 2021·Access Microbiology·Kim R BlasdellCadhla Firth
Nov 13, 2021·Environmental Science & Technology·Arnau Casanovas-MassanaFederico Costa

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Methods Mentioned

BETA
PCR
electrophoresis
PCRs

Software Mentioned

PCAmixdata
GoodmanKruskal
QGIS
R
AICcmodavg
lme4
R package glmulti

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