Association of Rosacea With Risk for Glioma in a Danish Nationwide Cohort Study

JAMA Dermatology
Alexander EgebergJacob P Thyssen

Abstract

Rosacea, a common facial skin disorder, has a poorly understood pathogenesis in which increased matrix metalloproteinase activity might play an important role. Glioma accounts for 80% of all primary malignant tumors in the central nervous system, and these tumors also show upregulation of certain matrix metalloproteinases. To investigate the association between rosacea and the risk for glioma. Nationwide cohort study of the Danish population from individual-level linkage of administrative registers. All Danish citizens 18 years or older from January 1, 1997, to December 31, 2011, were eligible for inclusion. A total of 5 484 910 individuals were eligible for analysis; of these, 68 372 had rosacea and 5 416 538 constituted the reference population. Data were analyzed from July 14 to August 10, 2015. The outcome of interest was a diagnosis of glioma. Incidence rates per 10 000 person-years were calculated, and incidence rate ratios adjusted for age, sex, and socioeconomic status were estimated by Poisson regression distribution models. Of the 5 484 910 individuals in the study population, 21 118 individuals developed glioma during the study period, including 20 934 of the 5 416 538 individuals in the reference population (50.4% w...Continue Reading

Citations

Sep 21, 2016·International Journal of Molecular Sciences·Yu Ri WooHyun Jeong Park
Jul 20, 2017·Journal of Neuro-oncology·Chenan ZhangKyle M Walsh
Feb 6, 2017·Dermatology and Therapy·Mauro PicardoJerry Tan
Dec 24, 2018·International Journal of Dermatology·Berna AksoyKamer Gunduz
Dec 23, 2019·Clinics in Dermatology·Uwe Wollina
Sep 25, 2021·Journal of the American Heart Association·Daein ChoiHyun-Sun Yoon
Apr 2, 2021·Case Reports in Dermatology·Nita WienholtzAlexander Egeberg

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