Abstract
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, and its prevalence is rapidly increasing in Han Chinese individuals. Several studies have demonstrated that polymorphisms of the PARVB gene may play crucial roles in the development of NAFLD. Therefore, the present study was designed to investigate the association of rs5764455 and rs6006473 polymorphisms in PARVB with the Han Chinese population's susceptibility to NAFLD. A total of 384 cases of NAFLD patients and 384 healthy controls were enrolled in this study. Their clinical information and serum biochemical indexes were analyzed. A sample (5 ml) of fasting venous blood was taken from each subject for DNA extraction, after which SNP probes were customized, and real-time PCR was used to detect SNP in the PARVB gene. Patients with genotype AA of rs5764455 SNP locus in PARVB gene had a higher incidence of NAFLD than patients with genotypes AG and GG (62.1% vs. 50.3% and 46.9%, respectively, p-values=0.034). Patients with genotype TT of rs6006473 SNP had a higher incidence of NAFLD than patients with genotypes CT and CC (56.9% vs. 49.9% and 42.0%, respectively, p-values=0.017). The ORs of the A allele and AA genotype of rs5764455 for NAFLD...Continue Reading
References
Aug 31, 2002·Journal of Gastroenterology and Hepatology·Katsuhisa OmagariShigeru Kohno
Mar 12, 2004·Journal of Gastroenterology and Hepatology·Shivakumar ChitturiJacob George
Dec 13, 2005·Journal of Gastroenterology and Hepatology·Jian-Gao FanShi-Yao Chen
May 19, 2006·Journal of Gastroenterology and Hepatology·Seung H ParkByung I Kim
Apr 4, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Nahum Méndez-SánchezMisael Uribe
May 15, 2007·Journal of Gastroenterology and Hepatology·Jian-Gao FanUNKNOWN Asia-Pacific Working Party for NAFLD
Dec 18, 2007·World Journal of Gastroenterology : WJG·Yong-Jian ZhouPin-Jin Hu
Nov 19, 2008·Journal of Hepatology·Jian-Gao Fan, Geoffrey C Farrell
Dec 24, 2009·Nature Reviews. Cancer·Jay S Desgrosellier, David A Cheresh
Apr 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca ValentiChristopher P Day
Aug 17, 2010·Gastroenterology·Naga ChalasaniUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Aug 31, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicola SantoroSonia Caprio
Dec 24, 2010·BMC Medical Genetics·Kikuko HottaAkhiro Sekine
Jun 11, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eleonora Patsenker, Felix Stickel
Jun 28, 2011·Science·Jonathan C CohenHelen H Hobbs
Oct 9, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Donna L WhiteHashem B El-Serag
Dec 12, 2012·PloS One·Xian-E PengXu Lin
Dec 14, 2012·World Journal of Gastroenterology : WJG·Yu-Yuan Li
Mar 29, 2013·Human Genetics·Takuya KitamotoKikuko Hotta
Mar 14, 2014·Journal of Human Genetics·Takuya KitamotoKikuko Hotta
Mar 26, 2014·Journal of Medical Genetics·Xiaoliang WangZhihai Peng
Feb 18, 2015·Journal of Hepatology·Xiaoliang WangWanqing Liu
Mar 18, 2015·Journal of Hepatology·Takuya KitamotoKikuko Hotta
Citations
Oct 5, 2016·Gene·Wenhui YangLi Yang
Aug 19, 2016·Medicine·Guohe SongXiaoliang Wang
Nov 5, 2019·Journal of Gastroenterology and Hepatology·Wen-Yue LiuMing-Hua Zheng
May 6, 2019·Journal of Dairy Science·S-L KleinS König
Feb 16, 2021·World Journal of Gastroenterology : WJG·Carlos Jose PirolaSilvia Sookoian