Association of rs5888 SNP in the scavenger receptor class B type 1 gene and serum lipid levels.

Lipids in Health and Disease
Dong-Feng WuShang-Ling Pan

Abstract

Bai Ku Yao is a special subgroup of the Yao minority in China. The present study was undertaken to detect the association of rs5888 single nucleotide polymorphism (SNP) in the scavenger receptor class B type 1 (SCARB1) gene and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. A total of 598 subjects of Bai Ku Yao and 585 subjects of Han Chinese were randomly selected from our stratified randomized cluster samples. Genotypes of the SCARB1 rs5888 SNP were determined by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) AI were lower but ApoB was higher in Bai Ku Yao than in Han (P < 0.05-0.001). The frequencies of C and T alleles were 78.3% and 21.7% in Bai Ku Yao, and 73.7% and 26.3% in Han (P < 0.01); respectively. The frequencies of CC, CT and TT genotypes were 60.0%, 36.6% and 3.4% in Bai Ku Yao, and 54.2%, 39.0% and 6.8% in Han (P < 0.01); respectively. The subjects with TT genotype in both ethnic groups had lower HDL-C and ApoAI le...Continue Reading

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Citations

Oct 24, 2012·International Journal of Medical Sciences·Dong-Feng WuCheng-Wu Liu
Mar 8, 2014·Molecular Medicine Reports·Wei WangTao Guo
Jun 5, 2017·Lipids in Health and Disease·C S PaththinigeVhw Dissanayake

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Methods Mentioned

BETA
PCR
electrophoresis
genotyping

Software Mentioned

Excel
SPSS

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