Association of salivary lipid peroxidation levels, antioxidant enzymes, and chronic periodontitis

The International Journal of Periodontics & Restorative Dentistry
Shilpa TrivediShivani Pandey

Abstract

This study assessed the activities of antioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR), and catalase (CAT) and free radical damage marker malondialdehyde (MDA) levels in saliva of 30 patients with chronic periodontitis (CP) compared to 30 healthy controls by spectrophotometry. MDA levels were significantly elevated in the CP group, whereas the SOD, CAT, and GR activities were significantly reduced compared to healthy controls. MDA levels demonstrated a significant direct correlation with all periodontal parameters, whereas all antioxidant enzymes studied (SOD, CAT, and GR) showed an inverse correlation. These findings support the idea that oxidative stress has a role in periodontal disease pathogenesis.

Citations

Jan 19, 2016·Journal of Periodontology·Yésica Alejandra Villa-CorreaSergio Iván Tobón-Arroyave
Jun 13, 2015·Archives of Oral Biology·Francisco Wilker Mustafa Gomes MunizRosimary de Sousa Carvalho
Dec 18, 2016·Clinical Oral Investigations·Thuy T NguyenRudee Surarit
Nov 29, 2017·Frontiers in Physiology·Yue WangXiaohui Rausch-Fan
Nov 6, 2015·Frontiers in Cellular and Infection Microbiology·L'ubomíra TóthováPeter Celec
Mar 10, 2020·Interventional Medicine & Applied Science·Andrii DemkovychPetro Hasiuk
Sep 30, 2017·Frontiers in Physiology·Jaya KumarPasuk Mahakknaukrauh
Mar 27, 2021·Biological Trace Element Research·Bertan Boran BayrakRefiye Yanardag

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