Association of secondhand tobacco smoke exposure during childhood on adult cardiovascular disease risk among never-smokers

Annals of Epidemiology
Maxwell PistilliREGARDS Investigators

Abstract

Adult secondhand tobacco smoke (SHS) exposure is related to stroke and coronary heart disease (CHD) risk, but long-term effects are less clear. We evaluated whether childhood SHS exposure affects subsequent stroke or CHD risk among adult black and white never-smokers followed for stroke and CHD. In this prospective cohort study, inverse probability weights were calculated to correct for bias due to attrition and survey nonresponse. Cox proportional hazards models were used to assess hazard ratios and 95% confidence intervals for stroke or CHD, separately, by number of childhood household smokers. Of 13,142 eligible participants, 6136 had childhood SHS exposure assessed. Baseline mean (SD) age was 63.5 (9.0), 65% were female, 30% black, 46% reported 0 childhood household smokers, 36% reported 1, and 18% reported 2+. In 60,649 person-years, 174 strokes were observed (2.9% of participants), and in 45,195 person-years, 114 CHD events were observed (2.1% of participants). The weighted and adjusted hazard ratios (95% confidence intervals) of stroke for 2+ versus 0 childhood household smokers was 1.66 (1.29-2.13) and was 1.15 (0.82-1.59) for CHD. We observed a significant association between childhood SHS exposure and stroke, but not ...Continue Reading

Citations

Jul 26, 2019·Journal of Atherosclerosis and Thrombosis·Shinji KatsuragiYoshihiro Miyamoto
Aug 14, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jonathan D KleinElissa A Resnick
Jan 22, 2020·The Journal of Obstetrics and Gynaecology Research·Shinji KatsuragiYoshihiro Miyamoto
Nov 1, 2020·Reviews on Environmental Health·Wei LiuWeihong Chen

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