Association of serotonin transporter promoter (5-HTTLPR) and intron 2 (VNTR-2) polymorphisms with treatment response in temporal lobe epilepsy

Epilepsy Research
Hrvoje HecimovicBranimir Jernej

Abstract

Temporal lobe epilepsy (TLE) is the most common epilepsy and about 30% of patients have poorly controlled seizures. Neurobiology underlying responsiveness to medical treatment in TLE patients is unclear and there are currently no biological tests to predict course of the disease. Animal and human studies repeatedly suggested serotonergic dysfunction in subjects with TLE. We investigated association of serotonin transporter (5-HTT) gene polymorphisms with medical treatment response in patients with TLE. We analyzed 5-HTT gene linked polymorphic region (5-HTTLPR) in promoter and variable number of tandem repeats in the second intron of the 5-HTT gene (VNTR-2) in 101 consecutive subjects with TLE. TLE patients with the combination of transcriptionally more efficient genotypes, i.e. 5-HTTLPR L/L and VNTR-2 12/12, had increased seizure refractoriness to antiepileptic medication therapy and shorter periods of seizure freedom, than subjects with other combinations of the 5-HTT genotypes. There were no other clinical or demographic differences among patient groups based on the 5-HTT genotypes. Combination of the 5-HTT genotypes linked with higher 5-HTT gene expression was found to be associated with worse response to optimal drug thera...Continue Reading

References

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Citations

Oct 16, 2012·Molecular Biology Reports·Marta CórdobaMarcelo Andrés Kauffman
Nov 5, 2011·Epilepsia·William H TheodoreSusumu Sato
Sep 8, 2012·Epilepsy Research and Treatment·Annick Salzmann, Alain Malafosse
Dec 19, 2013·Epilepsy Currents·Barry E Gidal
Oct 19, 2011·Biomarkers in Medicine·Tracy A Glauser
Jan 10, 2012·Epilepsy Research·Laila Cigana SchenkelMarino Muxfeldt Bianchin
May 31, 2011·Epilepsy & Behavior : E&B·Hrvoje HecimovicJohn J Barry
Apr 19, 2011·Epilepsy Research·Laila Cigana SchenkelMarino Muxfeldt Bianchin
Nov 29, 2016·Frontiers in Neuroscience·Dubravka Svob StracGiuseppe Di Giovanni
Oct 25, 2020·International Journal of Molecular Sciences·Sarita ThakranRitushree Kukreti

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