Association of serum apolipoprotein C III levels and apolipoprotein C III gene Sst I polymorphism with carotid intima-media thickness in Chinese type 2 diabetic patients

Diabetes Research and Clinical Practice
Xiang ChenRei Liu

Abstract

Apolipoprotein C III (apo C III) plays a central role in regulating plasma metabolism of triglyceride-rich lipoprotein (TRL). The G3238C allele (Sst I) in the 3'-untranslated region has been found to be associated with raised apo C III levels and hypertriglyceridemia (HTG). Some studies suggest that apo C III and the S(2) allele of apo C III gene are independent risk factors for atherosclerotic diseases. To study the potential association between these factors we analyzed the clinical data and their correlations with serum apo C III levels, apo C III gene Sst I polymorphism, and carotid intima-media thickness (IMT) in 78 unrelated Chinese patients with type 2 diabetes. Apo C III gene Sst I polymorphism was examined using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Carotid IMT was measured by color doppler ultrasound examination. Serum apo C III levels were found to be positively associated with plasma TG ( r = 0.527, P < 0.001), TC (r = 0.424, P < 0.001), LDL-C (r = 0.308, P < 0.01) concentrations, and carotid IMT (r =0.359, P < 0.01 ). Multivariate analysis (backward) showed that diastolic blood pressure, apo C III, and fasting insulin levels were independent risk factors of carotid IMT...Continue Reading

References

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Citations

Apr 28, 2006·Current Atherosclerosis Reports·Rebecca L Pollex, Robert Hegele
Dec 25, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Sandrine CaronBart Staels
Apr 1, 2014·Orvosi hetilap·Gábor Winkler
Aug 23, 2005·Diabetes/metabolism Research and Reviews
Apr 11, 2008·Clinical Science·Esther M M OoiGerald F Watts

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