PMID: 2124096Nov 1, 1990Paper

Association of serum IgM kappa monoclonicity in patients with Sjögren's syndrome with an increased proportion of kappa positive plasma cells infiltrating the labial minor salivary glands

Annals of the Rheumatic Diseases
Haralampos M MoutsopoulosC S Papadimitriou

Abstract

Minor salivary gland biopsy specimens from 11 patients with primary Sjögren's syndrome with circulating monoclonal IgM kappa cryoglobulins, seven without cryoglobulins, and four patients with rheumatoid arthritis and Sjögren's syndrome (one with monoclonal and three with polyclonal cryoglobulins) were examined by the peroxidase antiperoxidase bridge technique, using antihuman kappa and lambda antibodies. In 6/11 patients with primary Sjögren's syndrome and in one patient with Sjögren's syndrome and rheumatoid arthritis with monoclonal cryoglobulins a predominance of plasma cells containing intracytoplasmic kappa light chains was found (kappa:lambda greater than 3:1). Two of those seven patients had immunohistological features of immunocytomas. In the other five patients with circulating monoclonal cryoglobulins the kappa:lambda ratio of positive cells did not exceed 3:1, while six out of seven patients without cryoglobulins and the patients with rheumatoid arthritis and Sjögren's syndrome with polyclonal cryoglobulins had almost equal numbers of kappa and lambda stained cells. One of seven patients with primary Sjögren's syndrome without cryoglobulins had an increased number of lambda light chain positive cells, indicating a no...Continue Reading

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Citations

Mar 7, 2001·Arthritis and Rheumatism·M VoulgarelisH M Moutsopoulos
Nov 10, 2007·Clinical Reviews in Allergy & Immunology·Michael Voulgarelis, Fotini N Skopouli
May 8, 2002·Polskie Archiwum Medycyny Wewnętrznej·M Kopeć, E J Kucharz
Mar 1, 1993·European Journal of Clinical Investigation·P YouinouP M Lydyard
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P C Fox, P M Speight
Oct 1, 1995·Seminars in Arthritis and Rheumatism·E J Price, P J Venables
Dec 31, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S NakamuraK Nomoto
Oct 24, 2006·Oral Diseases·D I MitsiasH M Moutsopoulos
Jan 24, 2014·Expert Review of Clinical Immunology·Stavroula Giannouli, Michael Voulgarelis
Dec 1, 1990·Clinical and Experimental Immunology·P D KatsikisH M Moutsopoulos
Mar 1, 1996·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·R C Jordan, P M Speight
Aug 4, 2010·Acta otorrinolaringológica española·Iveth M Montoya-ArandaDiana J Gutiérrez-Tinajero

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