PMID: 16501668Feb 28, 2006Paper

Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas

Saudi Medical Journal
Zhou ZhongyinChen Jihong

Abstract

To investigate the relationship of serum lipids and apolipoprotein (apoE) gene polymorphism to colorectal adenomas. This study took place in the Department of Gastroenterology, Renmin Hospital of Wuhan University, PR China from June 2003 to March 2005. Ninety-eight patients with colorectal adenomas and 40 healthy subjects were enrolled, and their serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were determined. The apoE gene polymorphism was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum TC levels of colorectal adenomas group (5.32 +/- 0.85 mmol/L), distal colorectal adenomas group (5.58 +/- 0.63 mmol/L), and villous adenoma group (5.49 +/- 0.69 mmol/L) were higher than the control group (4.28 +/- 0.62 mmol/L, p=0.016), proximal colorectal adenomas group (4.82 +/- 0.58 mmol/L, p=0.038) and non-villous adenoma group (4.76 +/- 0.58 mmol/L, p=0.03). Serum HDL-C levels of colorectal adenomas group (1.39 +/- 0.25 mmol/L) were lower than the control group (1.51 +/- 0.29 mmol/L) (p=0.035). Serum lipids levels of each genotype in colorectal adenomas group were not statistically sign...Continue Reading

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Related Papers

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Zhi-jie XiaoJun Wu
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Shengwen HuangGuifang Li
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Ying TianBingwen Liu
© 2021 Meta ULC. All rights reserved