PMID: 9169895Jun 4, 1997Paper

Association of serum lipoprotein(a) levels and apolipoprotein(a) size polymorphism with target-organ damage in arterial hypertension

JAMA : the Journal of the American Medical Association
L A SechiE Bartoli

Abstract

To investigate the association between lipoprotein(a) [Lp(a)] and other plasma lipids and apolipoproteins and target-organ damage (TOD) in patients with arterial hypertension. Cross-sectional study of a case series. University medical center. Lipoprotein(a) and apolipoproteins were analyzed in 277 untreated patients with mild to moderate essential hypertension and in 102 healthy controls. Apolipoprotein(a) [apo(a)] phenotypes were additionally analyzed in an independent sample set of 106 hypertensive and 105 control subjects. Staging of TOD obtained according to World Health Organization guidelines by clinical evaluation, and laboratory tests including measurments of creatinine clearance, proteinuria, ophthalmoscopy, electrocardiography, echocardiography, and ultrasound examination of major arteries; levels of lipids, apolipoproteins, Lp(a), fibrinogen, and apo(a) phenotypes. Blood pressure, duration of hypertension, and levels of total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, Lp(a), and fibrinogen were significantly related to the presence and severity of TOD in univariate analysis. Stepwise multivariate analysis showed Lp(a) levels (P<.001) to be the best discriminator of the presence of TOD, follow...Continue Reading

Citations

Sep 13, 2014·Metabolism: Clinical and Experimental·Luigi MarzanoCristiana Catena
Jul 29, 2000·Australian and New Zealand Journal of Medicine·X L WangD E Wilcken
Jun 16, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry· Kalina AH Dieplinger
Jul 21, 1999·Kidney International. Supplement·G A Kaysen, M G de Sain-van der Velden
Nov 9, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Enzo EmanueleDiego Geroldi
Mar 28, 2002·Diabetes·Leonardo A SechiSergio De Marchi
Feb 6, 2013·American Journal of Hypertension·Cristiana CatenaLeonardo A Sechi
Oct 25, 2008·American Journal of Hypertension·Leonardo A SechiCristiana Catena
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R KleinG Evans
Jun 15, 2007·Journal of Hypertension·Marileda NovelloLeonardo A Sechi
Aug 12, 2005·Journal of Hypertension·Cristiana CatenaLeonardo A Sechi
Jul 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Cristiana CatenaLeonardo A Sechi
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Cristiana CatenaLeonardo A Sechi
Feb 24, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·L A Sechi, S De Marchi
Dec 4, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·A RosslG P Rossi
Jun 5, 2012·Journal of Atherosclerosis and Thrombosis·Cristiana CatenaLeonardo A Sechi
Mar 31, 2016·Clinical Diabetes and Endocrinology·Ramesh Saeedi, Jiri Frohlich
Mar 12, 2003·Critical Reviews in Clinical Laboratory Sciences·Giuseppe Lippi, Giancesare Guidi

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