Association of serum N(ε)-Carboxy methyl lysine with severity of diabetic retinopathy

Journal of Diabetes and Its Complications
Nibha MishraVinay K Khanna

Abstract

To correlate serum levels of N-epsilon-carboxy methyl lysine (N(ε)-CML) with severity of retinopathy, in vivo macular edema and disruption of external limiting membrane (ELM) and photoreceptor ellipsoid zone in type 2 diabetes mellitus (DM). Consecutive cases of type 2 DM [diabetes mellitus with no retinopathy (No DR) (n=20); non- proliferative diabetic retinopathy (NPDR) with diabetic macular edema (n=20); proliferative diabetic retinopathy with diabetic macular edema (PDR) (n=20)] and healthy controls (n=20) between the ages of 40 and 65years were included (power of study=93.8%). In vivo histology of retinal layers was assessed using spectral domain optical coherence tomography. Every study subject underwent macular thickness analysis using the macular cube 512×128 feature. Disruption of ELM and photoreceptor ellipsoid zone was graded: grade 0, no disruption of ELM and ellipsoid zone; grade 1, ELM disrupted and ellipsoid zone intact; grade 2, both ELM and ellipsoid zone disrupted. Data were statistically analyzed. The mean levels of N(ε)-CML were 31.34±21.23ng/ml, 73.88±35.01ng/ml, 91.21±66.65ng/ml, and 132.08±84.07ng/ml in control, No DR, NPDR and PDR respectively. N(ε)-CML level was significantly different between the study...Continue Reading

References

May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Mar 19, 1999·Biochemical and Biophysical Research Communications·A W StittH Vlassara
Mar 10, 2001·Recent Progress in Hormone Research·P Ulrich, A Cerami
Jan 19, 2002·Biochemical and Biophysical Research Communications·Sho-ichi YamagishiZenji Makita
Nov 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Helen VlassaraElliot J Rayfield
Jun 10, 2008·Investigative Ophthalmology & Visual Science·Ronald E GangnonUNKNOWN Early Treatment Diabetic Retinopathy Study Research Group
Dec 15, 2010·American Journal of Ophthalmology·Tomoaki MurakamiNagahisa Yoshimura
Feb 5, 2011·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Panagiotis G TheodossiadisGeorge P Theodossiadis
May 19, 2011·Current Diabetes Reports·Hongliang ZongAlan W Stitt
Jun 21, 2011·Investigative Ophthalmology & Visual Science·Rajeev R PappuruSrinivas R Sadda
Feb 1, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yumiko Akagi-KurashigeNagahisa Yoshimura
Feb 11, 2012·Investigative Ophthalmology & Visual Science·Tomoaki MurakamiNagahisa Yoshimura
Jun 12, 2013·Current Medicinal Chemistry·M ChenA W Stitt
Jun 22, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·N C ChilelliA Lapolla
Jul 20, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A K SharmaV E Laubach
Sep 28, 2013·Journal of Diabetes Research·Tomoaki Murakami, Nagahisa Yoshimura
Feb 14, 2015·Clinical & Experimental Ophthalmology·Shashi SharmaVinay K Khanna

❮ Previous
Next ❯

Citations

Jun 18, 2016·Frontiers in Physiology·Priyia PusparajahKhalid Abdul Kadir
Nov 9, 2019·International Journal of Retina and Vitreous·Gauhar NadriCarsten H Meyer
Jun 3, 2021·Antioxidants·Rocio Bautista-PérezJavier Flores-Estrada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis