Association of serum potassium concentration with mortality and ventricular arrhythmias in patients with acute myocardial infarction: A systematic review and meta-analysis

European Journal of Preventive Cardiology
Miriam Giovanna ColomboChrista Meisinger

Abstract

Background Challenging clinical practice guidelines that recommend serum potassium concentration between 4.0-5.0 mEq/L or ≥4.5 mEq/L in patients with acute myocardial infarction, recent studies found increased mortality risks in patients with a serum potassium concentration of ≥4.5 mEq/L. Studies investigating consequences of hypokalemia after acute myocardial infarction revealed conflicting results. Therefore, the aim of this systematic review and meta-analysis was to combine evidence from previous studies on the association of serum potassium concentration with both short and long-term mortality as well as the occurrence of ventricular arrhythmias. Design Systematic review and meta-analysis. Methods A structured search of MEDLINE and EMBASE databases yielded 23 articles published between 1990 and January 2017 that met the inclusion criteria. Study selection, data extraction and quality assessment were carried out by three reviewers. Random effects models were used to pool estimates across the included studies and sensitivity analyses were performed when possible. Results Twelve studies were included in the meta-analysis. Both pooled results from six studies investigating short-term mortality and from five studies examining lo...Continue Reading

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Citations

Mar 30, 2019·Journal of the American Heart Association·Benjamin BrueskeJacob C Jentzer
Nov 23, 2018·Frontiers in Physiology·Jonas Skogestad, Jan Magnus Aronsen
Feb 23, 2019·European Journal of Preventive Cardiology·Massimo F Piepoli
Jan 8, 2020·Medicines·Charat ThongprayoonStephen B Erickson
Feb 15, 2021·The American Journal of Emergency Medicine·Yoshifumi MizuguchiToshihisa Anzai
Feb 23, 2021·Frontiers in Cardiovascular Medicine·Gary TseWing Tak Wong

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