Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis

JAMA Neurology
Angela RosenbohmALS Registry Study Group

Abstract

Knowledge about the metabolic states of patients with amyotrophic lateral sclerosis (ALS) may provide a therapeutic approach. To investigate the association between the onset and prognosis of ALS and serum retinol-binding protein 4 (RBP4) concentration as a biomarker for insulin resistance and vitamin A metabolism. Case-control design for risk factors of ALS; cohort design for prognostic factors within ALS cases. Between October 1, 2010, and June 30, 2014, a population-based case-control study with randomly selected controls was established based on the ALS Registry Swabia in southern Germany, with a target population of 8.4 million inhabitants. Response rates were 64.8% among the cases and 18.7% among the controls. The dates of analysis were April 2016 to May 2017. Serum samples were measured for RBP4. Information on covariates was assessed by an interview-based standardized questionnaire. Main outcomes and measures were adjusted odds ratios for risk of ALS associated with serum RBP4 concentration, as well as time to death associated with RBP4 concentration at baseline in ALS cases only. Conditional logistic regression was applied to calculate multivariable odds ratios for risk of ALS. Survival models were used in cases only t...Continue Reading

Citations

Dec 19, 2019·Annals of Neurology·Albert C LudolphUNKNOWN LIPCAL-ALS Study Group
May 13, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J SchumacherUNKNOWN ALS Registry Swabia Study Group
Jun 23, 2020·Expert Review of Neurotherapeutics·Pamela A McCombeRobert D Henderson
Aug 15, 2018·JAMA Neurology·Javier RianchoAdolfo López de Munaín
Jun 13, 2020·Frontiers in Neuroscience·B KuraszkiewiczM de Carvalho
Aug 18, 2020·Expert Opinion on Drug Metabolism & Toxicology·Jason Nicol ClarkPeter McCaffery
Aug 15, 2018·JAMA Neurology·Gabriele NagelAlbert C Ludolph
Dec 5, 2018·Molecular Neurodegeneration·Ali JawaidPaul E Schulz
Jul 30, 2020·Stem Cell Reviews and Reports·Monika BarczewskaMariusz Grudniak
Feb 6, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rosario VastaAdriano Chiò

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