Association of serum total bilirubin level with severity of coronary atherosclerosis is linked to systemic inflammation

Atherosclerosis
Mehmet Kadri AkboğaAdnan Abaci

Abstract

Although cardiovascular protective action of bilirubin has been attributed to its antioxidant effect, there was scarce data regarding the anti-inflammatory properties. Herein, we aimed to assess the relationship between serum total bilirubin level and severity of coronary artery disease (CAD) in association with the direct inflammatory marker such as C-reactive protein (CRP), the other indirect markers included in inflammation process such as neutrophil to lymphocyte ratio (NLR) and red cell distribution width (RDW) in patients with stable CAD. Angiographic data of 1501 patients were analyzed in this retrospective cross-sectional study. Patients were categorized according to Gensini scores as control, mild CAD and severe CAD groups. The association of clinical and laboratory parameters with the severity of CAD were determined by multivariable linear regression analysis. Total bilirubin level in the control group was significantly higher than those of the other groups. After multivariable linear regression analysis total bilirubin [β=-3.131 (-4.481, -1.782), p<0.001] was significantly associated with the severity of CAD. Futhermore, there was a moderate and significant inverse correlation between serum total bilirubin level and ...Continue Reading

References

Dec 1, 1991·The Journal of Clinical Investigation·J L Witztum, D Steinberg
Feb 1, 1983·The American Journal of Cardiology·G G Gensini
Oct 1, 1995·Free Radical Biology & Medicine·P A DenneryD K Stevenson
Nov 13, 1998·Current Opinion in Lipidology·J L Witztum, J A Berliner
Mar 15, 2000·Coronary Artery Disease·Y OishiS Ito
Jun 19, 2002·Trends in Cardiovascular Medicine·Burkhard LudewigHans Hengartner
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jan 4, 2008·Circulation·Marcello TonelliUNKNOWN for the Cholesterol and Recurrent Events (CARE) Trial Investigators
Mar 7, 2009·Atherosclerosis·Maria DrakopoulouChristodoulos Stefanadis
Apr 10, 2010·International Heart Journal·Carine GhemCarlos A M Gottschall
Apr 22, 2011·BMJ : British Medical Journal·Lee C ClaridgeParamjit S Gill
Sep 26, 2013·The American Journal of Cardiology·Ki-Chul SungChristopher D Byrne
Mar 20, 2014·Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır·Aslı TanındıHasan Fehmi Töre

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Citations

Dec 15, 2015·Scandinavian Cardiovascular Journal : SCJ·Mehmet Kadri AkbogaDursun Aras
Oct 30, 2016·Journal of Clinical Laboratory Analysis·You-Fan PengGui-Dan Xu
Oct 25, 2016·International Journal of Cardiology·Mehmet Kadri AkbogaAdnan Abaci
Mar 10, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Emel AydinFatih Dede
Mar 1, 2017·Current Atherosclerosis Reports·Mario da Silva Garrote-FilhoNilson Penha-Silva
Nov 14, 2017·The International Journal of Neuroscience·Xiaohong LiWuning Mo
Sep 9, 2016·Physiological Reviews·Anita AyerRoland Stocker
Nov 22, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Nancy GuptaSachin Sule
Aug 5, 2017·Biomarkers in Medicine·Mehmet Kadri Akboga, Samet Yilmaz
Aug 21, 2018·Angiology·Mehmet Kadri AkbogaMustafa Karanfil
Apr 30, 2017·Journal of the American Heart Association·Dongdong WangAtanas G Atanasov
Sep 12, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Camilla MucciniAntonella Castagna
May 10, 2018·Angiology·Cengiz SabanogluSercan Okutucu
May 29, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Dan BingQiu-Ju Wang
May 29, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Heidi M CraneJoseph A C Delaney
Jun 18, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hiroaki TsujikawaTakanari Kitazono
Apr 13, 2019·Current Neurovascular Research·Xiaoxiao TaoXingquan Zhao
Feb 3, 2016·The Journal of Veterinary Medical Science·Takehiro OchiHironari Koyama
Sep 10, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Chaudry N MajeedElsayed Z Soliman
Oct 9, 2015·American Journal of Therapeutics·Nancy GuptaSachin Sule
Aug 18, 2018·Experimental and Therapeutic Medicine·Qiang ZhangChangxia Dong
Apr 19, 2017·Archives of Pathology & Laboratory Medicine·You-Fan Peng, Yi-Bin Deng
Feb 20, 2018·Experimental and Therapeutic Medicine·Li ZhangKun Song
Jun 1, 2019·Mediators of Inflammation·Xiaojing ZhaoHongjie Zhang
Feb 23, 2019·Interventional Medicine & Applied Science·Hakan Duman, Songül Özyurt
Feb 26, 2019·Angiology·Mehmet Kadri Akboga, Yesim Eylev Akboga
Jul 28, 2019·International Journal of Molecular Sciences·Yoshimi KishimotoYukihiko Momiyama
Aug 21, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Xue-Biao WeiJi-Yan Chen

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