Association of serum uric acid and incident nonspine fractures in elderly men: the Osteoporotic Fractures in Men (MrOS) study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Nancy E LaneOsteoporotic Fractures in Men Study Group

Abstract

Uric acid (UA) is produced from purines by the enzyme xanthine oxidase, and elevated levels may cause arthritis and kidney stones. Conversely, UA also appears to function as an antioxidant and may protect against the oxidative stress associated with aging and disease. We performed a prospective fracture case-cohort study to understand the relation of UA and fracture risk in older men enrolled in the Osteoporotic Fractures in Men (MrOS) study. In the cohort of 5994 men aged 65 years and older attending the baseline MrOS examination, we evaluated a subgroup 1680 men in a case-cohort study design. The analytic group included 387 men with incident nonspine fractures (73 hip) and a random sample of 1383. Serum UA was measured in baseline serum samples. Modified proportional hazards models that account for case-cohort study design were used to estimate the relative hazards (RH) of hip and nonspine fracture in men for serum UA. Models were adjusted for age, race, clinic site, body mass index, vitamin D, parathyroid hormone, walking speed, Physical Activity Scale for the Elderly (PASE) score, frailty, and total. Subjects with incident nonspine fractures were older, had lower total hip bone mineral density (BMD), and higher serum phosph...Continue Reading

References

Nov 20, 1983·Nihon Naibunpi Gakkai zasshi·M YonedaA Tomita
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein
Apr 17, 1999·Scandinavian Journal of Clinical and Laboratory Investigation·E J ErlandsenJ H Kristensen
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Nov 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gwen S ScottD Craig Hooper
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Dario MaggioAntonio Cherubini
Feb 5, 2005·Stroke; a Journal of Cerebral Circulation·Hui ShenYun Wang
Aug 9, 2005·Contemporary Clinical Trials·Janet Babich BlankRomelia Ramírez Delay
Dec 27, 2005·Current Pharmaceutical Design·D MasseoudC Agudelo
Dec 27, 2005·Current Pharmaceutical Design·G K GlantzounisD A Galaris
Oct 25, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cora E LewisUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Jul 31, 2007·Journal of the American Geriatrics Society·Peggy M CawthonUNKNOWN Osteoporotic Fractures in Men Research Group
Sep 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SugiuraM Yano
Oct 24, 2007·Neurology·Alvaro AlonsoMiguel A Hernán
Nov 6, 2007·Diabetes Care·Abbas DehghanJacqueline C M Witteman
Feb 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A StevensAndrew S Levey
Mar 20, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe LippiGiovanni Targher
Sep 30, 2008·Cleveland Clinic Journal of Medicine·Brian F Mandell
Mar 21, 2009·American Journal of Epidemiology·Honglei ChenXuemei Huang
Apr 3, 2009·Current Opinion in Rheumatology·N Lawrence Edwards
May 21, 2009·The Journal of Clinical Endocrinology and Metabolism·Kristine E EnsrudUNKNOWN Osteoporotic Fractures in Men Study Group
May 26, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Omer Faruk SendurMukadder Serter
Jul 1, 2009·Arthritis and Rheumatism·Seo Young KimDaniel A Albert
Feb 4, 2011·Journal of the American Geriatrics Society·Christine G LeeUNKNOWN Osteoporotic Fractures in Men Study Group
May 5, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Iraj NabipourMarkus J Seibel
Aug 23, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A InkerJosef Coresh
Jun 26, 2012·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Chanika SritaraPiyamitr Sritara
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Dec 14, 2012·Nephron. Experimental Nephrology·Laura Gabriela Sánchez-LozadaRichard J Johnson
May 7, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S H AhnG S Kim

❮ Previous
Next ❯

Citations

Mar 29, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B-J KimJ-M Koh
Nov 22, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A XiongZ Zhang
Dec 11, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dihua ZhangKhashayar Sakhaee
Dec 17, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicola DalbethTony R Merriman
Dec 11, 2014·Metabolism: Clinical and Experimental·Tapan MehtaDiana Jalal
Mar 4, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J L HernándezJ M Olmos
Sep 24, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Jérémy FlaisPascal Guggenbuhl
Dec 4, 2012·Bone·J-M KaufmanR Rizzoli
Oct 12, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M PirroT Merriman
Oct 28, 2016·European Journal of Clinical Investigation·Nicola VeroneseEmanuele Cereda
Aug 20, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Seoyoung C KimDaniel H Solomon
Sep 3, 2016·Arthritis & Rheumatology·Julie M PaikGary C Curhan
Feb 3, 2016·Therapeutic Advances in Musculoskeletal Disease·Peggy M CawthonNancy E Lane
Jul 14, 2018·Acta Clinica Belgica·Atalay DogruMehmet Sahin
Aug 26, 2016·Medicine·Huey-En TzengChun-Hao Tsai
Aug 29, 2019·Journal of Orthopaedic Surgery and Research·Fanxiao LiuFei Xiong
Dec 2, 2017·Current Opinion in Rheumatology·Ian Chang, David Gazeley
Aug 5, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Catherine CormierJean-Claude Souberbielle
Dec 20, 2015·The Journal of Clinical Endocrinology and Metabolism·Taulant MukaFernando Rivadeneira
May 11, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P YinP Tang
Jan 12, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D SimonR Kocijan
Oct 12, 2017·Calcified Tissue International·Nicola DalbethJillian Cornish
Sep 8, 2019·Nutrients·Kun-Mo LinKuo-Cheng Lu
Oct 14, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Ronny IsnuwardanaAmmarin Thakkinstian
Apr 20, 2021·Frontiers in Endocrinology·Wisam Nabeel IbrahimMarawan Abdelhamid Abu-Madi
Jun 10, 2021·Scientific Reports·Jung Woo LeeHyo Geun Choi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
B EttingerOsteoporotic Fracture in Men (MrOS) Study Research Group
Seminars in Arthritis and Rheumatism
A R Mawson, G I Onor
Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Rajendra K Marwah
Clinical Chemistry
Krzysztof Safranow, Zygmunt Machoy
© 2021 Meta ULC. All rights reserved