Association of serum uric acid change with mortality, renal function and diuretic dose administered in treatment of acute heart failure

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
H-B ZhouD-L Xu

Abstract

Hyperuricemia is reportedly associated with poor outcome in acute heart failure (AHF). The association between changes in Uric acid (UA) levels with renal function change, diuretic doses, and mortality in patients with AHF were studied. Consecutive patients hospitalized with AHF were reviewed (n = 535). UA levels were measured at admission and either at discharge or on approximately the seventh day of admission. Patients with an UA change in the top tertile were defined as having an increase (UA-increase) and were compared to those outside the top tertile (non-UA-increase). The endpoint was all-cause mortality, with a mean follow-up duration of 22.2 months. Patients in the UA-increase group presented with greater creatine increase (P < 0.001), and were administered a higher average daily dose of loop diuretic (P = 0.016) compared with the non-UA-increase group. In-hospital UA-increase was associated with higher risk of mortality even after adjusting for confounding variables including creatine change and diuretic dosage [harzard ratio (HR) 1.53, 95% confidence interval (CI) 1.02-2.30, P = 0.042]. In patients with hyperuricemia on admission, UA-increase was associated with increased mortality (adjusted HR 2.21, 95% CI 1.38-3.52,...Continue Reading

Citations

Nov 27, 2020·Journal of Hypertension·Alessandro MalobertiUNKNOWN Working Group on Uric Acid, Cardiovascular Risk of the Italian Society of Hypertension (SIIA)
Oct 9, 2021·Frontiers in Cardiovascular Medicine·Qiu-Hong TanYing-Qing Feng

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