Association of serum/plasma high mobility group box 1 with autoimmune diseases: A systematic review and meta-analysis

Medicine
Bin ZhuShanshan Liu

Abstract

High mobility group box 1 (HMGB1) is a kind of proinflammatory mediator to stimulate the innate and adaptive immune system and participates in a number of acute and chronic inflammatory processes after sterile injury or microbial invasion. HMGB1 has been suggested to be involved in the pathogenesis of many autoimmune diseases. However, the results are contradictory or inconclusive among these findings. The aim of this study was to investigate whether serum/plasma HMGB1 levels are associated with autoimmune diseases by comparing the serum/plasma HMGB1 levels in patients with autoimmune disease and healthy controls and to further evaluate whether serum/plasma HMGB1 levels are associated with disease state. PubMed, Medline, and Web of science databases (up to October 1, 2017) were used to obtain all relative published literature. Study quality was assessed by the Newcastle-Ottawa scale (NOS). Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effects or random-effect model analysis. A total of 23 original articles of autoimmune diseases were finally included in the meta-analysis. Results revealed that the serum/plasma HMGB1 levels were increased in patients with autoimmune disease, comp...Continue Reading

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Citations

Oct 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Tianye LiuBetty Diamond
Nov 16, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maria BucovaMilan Buc
Jan 15, 2020·Canadian Journal of Physiology and Pharmacology·Di WangShiren Sun
Feb 6, 2020·Experimental and Therapeutic Medicine·Xintian CaiNanfang Li
Aug 6, 2019·Frontiers in Immunology·Carolina M GorgulhoMichael T Lotze
Jul 16, 2020·Clinical and Experimental Pediatrics·Kyung-Yil LeeJin-Han Kang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

GetData Graph Digitizer
Stata

Related Concepts

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