Association of Severity and Prognosis With Elevated Homocysteine Levels in Patients With Intracerebral Hemorrhage

Frontiers in Neurology
Dandan WangXingquan Zhao

Abstract

Background: Intracerebral hemorrhage (ICH) has high mortality and morbidity rates in the world. Homocysteine (Hcy) has been demonstrated to be an independent risk factor and could predict the prognosis and recurrence of ischemic stroke. In our study, we aimed to find out the relationship between Hcy levels and the severity and prognosis of patients with ICH. Methods: Patients' basic characteristics and laboratory examination results, including the concentration of homocysteine, were taken at baseline from January 2014 to September 2016, and a 1 year follow-up, including the modified Rankin Scale and living status, was taken for all the patients. Logistic regression and Kaplan-Meier survival method were used to analyze the relationship between different Hcy levels and clinical outcome. Results: A total of 551 patients with acute ICH from 13 hospitals in Beijing were enrolled in our study. High Hcy was detected in 284 patients (51.5%). Percentage of male, smoking, drinking, and concentration of hemoglobin A1c and triglyceride levels showed a significant difference between different Hcy level groups (all P-values <0.05). In the logistic regression analysis, high Hcy level is an independent risk factor for the prevalence of 3 month...Continue Reading

References

May 26, 1999·JAMA : the Journal of the American Medical Association·P M RidkerC H Hennekens
Mar 20, 2001·The Journal of Clinical Investigation·M A HofmannA M Schmidt
Dec 4, 2010·Antioxidants & Redox Signaling·Mesia M Steed, Suresh C Tyagi
Jul 10, 2014·Current Medicinal Chemistry·Sathnur PushpakumarUtpal Sen
Jan 13, 2015·Nutrition Journal·Paul Ganguly, Sreyoshi Fatima Alam
Jan 27, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Fangfang ZhouZhiping Hu
Jul 23, 2015·Stroke; a Journal of Cerebral Circulation·Zhihong ShiYong Ji
Oct 8, 2017·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Junjie ZhaoKui Yang
Jul 7, 2018·Expert Review of Cardiovascular Therapy·Steven G Chrysant, George S Chrysant
Oct 16, 2018·Lancet·Charlotte CordonnierCraig S Anderson
Feb 20, 2019·International Journal of Molecular Sciences·Ruben EsseRita Castro
Mar 18, 2019·Lancet Neurology·Simiao WuUNKNOWN China Stroke Study Collaboration
Jan 17, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Jiejie LiUNKNOWN CHANCE Investigators

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