Association of sex hormones with carotid artery distensibility in men and postmenopausal women: multi-ethnic study of atherosclerosis

Hypertension
Dhananjay VaidyaPamela Ouyang

Abstract

The decline in carotid distensibility with age is steeper in women than in men, however, the correlates of this sex difference are not known. We examined the association of bioavailable testosterone, estradiol, dehydroepiandrosterone, and sex hormone-binding globulin, in 2783 postmenopausal women and 2987 men aged 45 to 84 years at the Multi-Ethnic Study of Atherosclerosis baseline examination. Carotid artery lumen diameters by ultrasound and brachial artery blood pressures were measured at systole and diastole. Regression models to determine the association of carotid distensibility coefficient and lumen diameter with sex-specific quartiles of sex hormones were adjusted for age, race, height, weight, diabetes mellitus, current smoking, antihypertensive medication use, total and high-density lipoprotein cholesterol levels, and hormone replacement therapy in women. A higher DC indicates a more distensible vessel. In women, higher dehydroepiandrosterone (P=0.008) and lower sex hormone-binding globulin (P=0.039) were associated with lower distensibility; higher dehydroepiandrosterone and lower estradiol were associated with smaller carotid diameters. In men, higher Bio-T (P=0.009) and lower estradiol (P=0.007) were associated with...Continue Reading

References

Dec 29, 1995·Annals of the New York Academy of Sciences·E Barrett-Connor, D Goodman-Gruen
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Jun 19, 2001·Aging : Clinical and Experimental Research·A ScuteriJ L Fleg
Feb 21, 2002·American Journal of Obstetrics and Gynecology·Kenny A Rodriguez-MaciasDavid Bergqvist
Sep 15, 2005·American Journal of Physiology. Endocrinology and Metabolism·Hidetaka HougakuE Jeffrey Metter
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Jan 25, 2007·The Journal of Clinical Endocrinology and Metabolism·Sherita Hill GoldenPamela Ouyang
Jan 29, 2009·European Journal of Endocrinology·Marianna YaronNaftali Stern
Oct 1, 2009·The Journal of Clinical Endocrinology and Metabolism·Rita Rastogi KalyaniSherita Hill Golden
Feb 15, 2011·The Journal of Obstetrics and Gynaecology Research·Aiko SasakiMikiya Nakatsuka
Feb 25, 2011·Journal of Hypertension·Pascal RossiAnna A Ahimastos
Jan 25, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D VaidyaP Ouyang
Feb 18, 2014·Atherosclerosis·Charalambos VlachopoulosChristodoulos Stefanadis
Apr 10, 2014·The Journal of Clinical Endocrinology and Metabolism·Grace HuangShehzad Basaria

❮ Previous
Next ❯

Citations

Jul 15, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Xiao-Xia LiYan-Hua Shan
May 4, 2018·American Journal of Hypertension·Kaisa M Mäki-Petäjä, Ian B Wilkinson
Dec 24, 2018·Experimental Physiology·Rachel M StoneMichael M Tymko
Oct 16, 2016·Global Heart·Nancy Swords JennyRussell P Tracy
Jun 28, 2017·Current Treatment Options in Cardiovascular Medicine·Dipti GuptaRichard M Steingart
May 14, 2020·Reproductive Biology and Endocrinology : RB&E·Jonna LeppänenSeppo Heinonen
Dec 6, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Chih-Fan YehHsien-Li Kao
Nov 14, 2020·Journal of Hypertension·Tan Lai ZhouThomas T van Sloten
Feb 14, 2021·European Journal of Preventive Cardiology·E AribasM Kavousi
Feb 22, 2021·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Christiana TsirimiagkouAthanase D Protogerou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.