Association of SGK1 gene polymorphisms with type 2 diabetes

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Matthias SchwabFlorian Lang

Abstract

The serum and glucocorticoid inducible kinase SGK1 is genomically upregulated by glucocorticoids and in turn stimulates a variety of carriers and channels including the renal epithelial Na(+) channel ENaC and the intestinal Na(+) glucose transporter SGLT1. Twin studies disclosed an association of a specific SGK1 haplotype with moderately enhanced blood pressure in individuals who are carrying simultaneously a homozygous genotype for a variant in intron 6 [I6CC] and a homozygous or heterozygous genotype for the C allele of a polymorphism in exon 8 [E8CC/CT] of the SGK1 gene. A subsequent study confirmed the impact of this risk haplotype on blood pressure. SGK1 knockout mice are resistant to the insulin and high salt induced increase of blood pressure, glucocorticoid induced increase of electrogenic glucose transport, and glucocorticoid induced suppression of insulin release. The present study explored whether the I6CC/E8CC/CT haplotype impacts on the prevalence of type 2 diabetes. The prevalence of the I6CC genotype was 3.1% in a healthy German, 2.4 % in a healthy Romanian and 11.6 % in a healthy African population from Ghana (p=0.0006 versus prevalence in Caucasians). Comparison of genotype frequencies between type 2 diabetic p...Continue Reading

References

Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S WaldeggerF Lang
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Y ChenD Pearce
Jun 8, 1999·The Journal of Biological Chemistry·A Náray-Fejes-TóthG Fejes-Tóth
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·J M KumarN J Laping
Apr 6, 2000·American Journal of Physiology. Renal Physiology·A ShigaevE Reuveny
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·F LangS Broër
Sep 21, 2000·Molecular and Cellular Endocrinology·F E Brennan, P J Fuller
Nov 1, 2000·Cell·A Toker, A C Newton
Nov 28, 2000·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·C BöhmerF Wehner
Dec 10, 2000·The Journal of Biological Chemistry·N PerrottiS I Taylor
Feb 24, 2001·American Journal of Physiology. Renal Physiology·J WangD Pearce
Mar 16, 2001·American Journal of Physiology. Renal Physiology·J LoffingF Verrey
Apr 3, 2001·Current Pharmaceutical Design·A S Wagman, J M Nuss
Aug 15, 2001·Lancet·E SchaeffelerM Schwab
Aug 18, 2001·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·C A WagnerF Lang
Nov 7, 2001·The Journal of Biological Chemistry·Peter M SnyderBrittany C Thomas
Dec 4, 2001·Brain Research. Molecular Brain Research·S KumariS R D'Mello
Dec 26, 2001·The Journal of Biological Chemistry·C Chris YunFlorian Lang
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Carla J FalettiBonnie L Blazer-Yost
Jul 12, 2002·Pflügers Archiv : European journal of physiology·Iwan SetiawanFlorian Lang
Sep 7, 2002·Hypertension·Andreas BusjahnFlorian Lang
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Diego Alvarez de la Rosa, Cecilia M Canessa
Oct 24, 2002·Nutrition Reviews·Julie L RothMarguerite Clohisy
Oct 25, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·V BährS Diederich
Feb 19, 2003·Kidney & Blood Pressure Research·Guido HenkeFlorian Lang
Mar 14, 2003·Pflügers Archiv : European journal of physiology·Hamdy M EmbarkFlorian Lang
Mar 22, 2003·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Gary L FirestoneBridget A O'Keeffe
Mar 22, 2003·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·C Chris Yun
Mar 22, 2003·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Andreas Busjahn, Freidrich C Luft
May 29, 2003·American Journal of Physiology. Renal Physiology·Michelle L GumzBrian D Cain
Jun 6, 2003·Biochemical and Biophysical Research Communications·Christoph BoehmerF Lang

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Citations

Jul 9, 2009·Current Opinion in Nephrology and Hypertension·Florian LangVolker Vallon
Jan 22, 2011·Acta Physiologica·A T UmbachF Lang
May 15, 2010·BMC Genetics·Angelica B W BoldtJürgen F J Kun
Aug 23, 2011·Ghana Medical Journal·Jairo A Garcia A, Lewis R Roberts
Nov 1, 2011·Clinical and Experimental Nephrology·Florian Lang, Volker Vallon
Sep 1, 2011·Diabetes Research and Clinical Practice·Silke A SchäferKonstantinos Kantartzis
Aug 28, 2014·The Journal of Membrane Biology·Bernat ElviraFlorian Lang
Sep 18, 2015·Cell Death & Disease·D PastoreD Lauro
Nov 10, 2012·The Journal of Steroid Biochemistry and Molecular Biology·H Wolden-KirkC Mathieu
Dec 22, 2009·Expert Opinion on Therapeutic Patents·Florian Lang, Agnes Görlach
Dec 5, 2014·Pflügers Archiv : European journal of physiology·Katrina J BingerMarkus Kleinewietfeld
Jun 12, 2016·Journal of Molecular Endocrinology·Ping LiDa-Long Zhu
Aug 16, 2016·International Journal of Molecular Sciences·Yiyun LouFan Jin
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Teresa F AckermannFlorian Lang
Dec 18, 2010·Journal of the American Society of Nephrology : JASN·Florian Lang
Sep 15, 2009·Endocrine Reviews·Harald StaigerHans-Ulrich Häring
Oct 6, 2010·Growth Factors·Maressa A BruhnKaren E Sheppard
Feb 19, 2020·Expert Opinion on Therapeutic Targets·Inés MaestroAna Martinez
Sep 27, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Florian Lang, Ekaterina Shumilina
Sep 22, 2009·Expert Opinion on Therapeutic Targets·Florian LangVolker Vallon
Aug 1, 2015·Personalized Medicine·Khalid Siddiqui, Shivani Tyagi
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Florian LangMadhuri S Salker
Feb 16, 2021·American Journal of Physiology. Renal Physiology·Catalina Sierra-RamosDiego Alvarez de la Rosa
Apr 24, 2021·Human Molecular Genetics·Montasir ElahiNobutaka Hattori

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