PMID: 11329406May 1, 2001Paper

Association of short-term response to haloperidol treatment with a polymorphism in the dopamine D(2) receptor gene

The American Journal of Psychiatry
M SchäferH J Möller

Abstract

Pharmacogenetic influences on therapeutic response to neuroleptic treatment are poorly understood. This study investigates the association of response to short-term haloperidol treatment with a Taq I polymorphism in the DRD2 gene. Fifty-seven patients with acute psychosis were treated with haloperidol for up to 28 days. Improvement and response were measured by using the Positive and Negative Syndrome SCALE: Forty-one patients were homozygous for allele 2, and 16 were heterozygous. Heterozygous patients showed a greater improvement in positive, but not in negative, symptoms on all treatment days than patients homozygous for allele 2. Differences in improvement of positive symptoms reached statistical significance on days 14, 21, and 28. On treatment day 14, 10 (62.5%) of 16 heterozygous patients had at least 50% improvement of positive symptoms, compared with 11 (28.9%) of 38 homozygous patients. These results support the hypothesis that genetic variations in the DRD2 gene may influence the individual response to antipsychotics.

Citations

May 1, 2001·Yeast·C CompagnoD Porro
Jun 9, 2004·Neurotoxicity Research·Tomas PalomoRrichard J Beninger
Aug 16, 2012·European Archives of Psychiatry and Clinical Neuroscience·Ina GieglingDan Rujescu
Mar 25, 2004·Current Psychiatry Reports·Amlan BasuKathy Aitchison
Sep 21, 2007·Current Psychiatry Reports·Charles U Nnadi, Anil K Malhotra
Mar 17, 2004·Current Opinion in Pharmacology·Brigitta Bondy, Peter Zill
Sep 18, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Antonio DragoDan Rujescu
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Giuseppe Blasi, Alessandro Bertolino
Dec 24, 2003·Journal of Psychiatric Research·Ming T TsuangStephen V Faraone
Sep 27, 2003·Toxicology·M J Arranz, R W Kerwin
Jan 22, 2009·European Journal of Human Genetics : EJHG·Anna C NeedDavid B Goldstein
Mar 19, 2008·The Pharmacogenomics Journal·D F HeitjanC Lerman
May 31, 2012·Cerebral Cortex·David M ColeChristian F Beckmann
Aug 30, 2008·Schizophrenia Bulletin·Maria J Arranz, Shitij Kapur
Aug 26, 2010·Pharmacogenetics and Genomics·Huaiyu MiRuss B Altman
May 18, 2013·BMC Medicine·Uzoezi OzomaroCharles B Nemeroff
Sep 6, 2001·Pharmacogenomics·J Scharfetter
May 17, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Chiaki Kawanishi
Dec 19, 2007·Pharmacogenomics·Sonya VastoCalogero Caruso
Mar 21, 2002·Expert Review of Molecular Diagnostics·R W KerwinM J Arranz
Sep 16, 2008·L'Encéphale·V Moulier, D Januel
Mar 15, 2012·International Journal of Psychiatry in Clinical Practice·Nienke C C VulinkDamiaan Denys
Dec 18, 2010·Expert Opinion on Drug Metabolism & Toxicology·Jian-Ping Zhang, Anil K Malhotra
Sep 14, 2010·Clinics in Laboratory Medicine·Peter P Zandi, Jennifer T Judy
Sep 14, 2010·Clinics in Laboratory Medicine·Adriana FosterPeter Buckley
Feb 18, 2010·The Psychiatric Clinics of North America·Peter P Zandi, Jennifer T Judy
Dec 9, 2008·Clinics in Laboratory Medicine·Bronwyn Ramey-HartungKristen K Reynolds
Sep 13, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jun Soo KwonUNKNOWN APLUS study group
Dec 19, 2007·Journal of Psychiatric Research·Malin AleniusMargareta Hammarlund-Udenaes
Aug 28, 2007·The Psychiatric Clinics of North America·Adriana FosterPeter F Buckley
Feb 8, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Gavin P ReynoldsZhiJun Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here