Association of Single-Nucleotide Polymorphism in the Hepcidin Promoter Gene with Susceptibility to Extrapulmonary Tuberculosis

Genetic Testing and Molecular Biomarkers
Li LiangHeping Xiao

Abstract

Hepcidin is a 25-amino acid peptide produced by the liver in response to inflammation and iron overload. It is encoded by the hepcidin antimicrobial peptide (HAMP) gene and plays a key role in innate immunity. Previous studies have reported that a -582 A>G polymorphism in the HAMP promoter (HAMP-P) affects hepcidin expression, causing susceptibility to various bacterial and viral pathogens. However, it is not known whether the HAMP-P -582 A>G polymorphism is associated with tuberculosis (TB) susceptibility. The objective of the current study was to examine the relationship between the HAMP-P -582 A>G polymorphism and TB susceptibility in a Chinese Han population. Han Chinese subjects examined included 500 pulmonary TB, 386 extrapulmonary TB, and 600 healthy control subjects. We analyzed correlations between the hepcidin promoter -582 A>G polymorphism and disease susceptibility and then examined the regulatory effects of the -582 A>G variant on hepcidin production in CD14+ monocyte cultures stimulated with lipoarabinomannan derived from Mycobacterium tuberculosis. Our findings indicate that the HAMP-P -582 A>G polymorphism (rs10421768) is associated with susceptibility to extrapulmonary TB, but not pulmonary TB. CD14+ monocytes ...Continue Reading

References

Dec 13, 2000·The Journal of Biological Chemistry·C H ParkT Ganz
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·G NicolasS Vaulont
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gaël NicolasSophie Vaulont
Jul 18, 2002·Journal of Inorganic Biochemistry·Robert R CrichtonRoberta J Ward
May 14, 2003·Archives of Internal Medicine·Elizabeth L CorbettChristopher Dye
Sep 4, 2003·The Journal of Experimental Medicine·Dirk SchnappingerGary K Schoolnik
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Juliano TimmJohn D McKinney
Jan 31, 2004·Blood·Abas H LaftahSurjit K S Srai
Nov 30, 2004·The Lancet Infectious Diseases·Esther van de VosseTom H M Ottenhoff
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mitchell D KnutsonMarianne Wessling-Resnick
Apr 20, 2005·Clinics in Chest Medicine·Richard Bellamy
May 12, 2007·The Journal of Infectious Diseases·Johan R BoelaertVictor R Gordeuk
Jul 5, 2007·Journal of Leukocyte Biology·Fatoumata B SowWilliam P Lafuse
Mar 15, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Li LiangHeping Xiao
Oct 29, 2011·Microbes and Infection·Erin E Johnson, Marianne Wessling-Resnick

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Citations

Mar 14, 2019·Journal of Clinical Medicine·Laura M VilanderThe Finnaki Study Group
May 4, 2021·Frontiers in Microbiology·Julio FloresLeslie Chavez-Galan

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Methods Mentioned

BETA
gene knockdown
PCR
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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