Association of Single Nucleotide Polymorphisms in the MD-2 Gene Promoter Region With Der p 2 Allergy

Allergy, Asthma & Immunology Research
En Chih LiaoJaw Ji Tsai

Abstract

Sensitization to house dust mite (Dermatophagoides pteronyssinus) is a considerable risk factor for the progression of allergic disease. The group 2 allergen from Dermatophagoides pteronyssinus, Der p 2, is considered a major one in patients with specific immunoglobulin E (IgE) to Der p 2. Der p 2 has structural homology with myeloid differentiation 2 (MD-2), which is involved in the lipopolysaccharide-binding component of the Toll-like receptor 4 signaling pathway and the development of inflammation. The aim of this study was to examine the genetic association of single nucleotide polymorphisms (SNPs) in the promoter region of MD-2 with Der p 2-sensitive allergy. We investigated associations between cohort's characteristics, including 280 allergic and 80 healthy subjects by examining total IgE, eosinophils, D. pteronyssinus-specific IgE, Der p 2-specific IgE, the number of IgE-producing B cells induced by Der p 2, and the odds ratio of allergic symptoms. Based on the 1,000 genome project data, the minor allele frequencies of the rs1809441 and rs1809442 are 0.467 and 0.474, respectively. However, the correlation of linkage disequilibrium (LD) between these 2 SNPs is D'=1, the genotype frequencies of the 2 MD-2 (LY96) SNPs (rs18...Continue Reading

References

Sep 9, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·G SchuetzeJ Kuehr
Aug 8, 2002·Current Allergy and Asthma Reports·Larry G ArlianJacqueline S Neal
Sep 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A P F TromboneL K Arruda
Jun 5, 2003·Molecular Biology and Evolution·Gregory A WrayLaura A Romano
Nov 19, 2003·Scandinavian Journal of Infectious Diseases·Masao KimotoKensuke Miyake
Aug 10, 2005·Seminars in Respiratory and Critical Care Medicine·David Zaas, David A Schwartz
Sep 17, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G D'AmatoS Holgate
May 29, 2009·Environmental Research·Janneane F GentBrian P Leaderer
Dec 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Simpson, F D Martinez
Mar 25, 2010·The British Journal of Dermatology·M E SchramPh I Spuls
May 19, 2010·Expert Review of Clinical Immunology·Wayne R Thomas
Sep 24, 2010·The New England Journal of Medicine·Miriam F MoffattUNKNOWN GABRIEL Consortium
Feb 1, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Loubna Akhabir, Andrew J Sandford
Aug 11, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ann Houston WilliamsJane E Gallagher
Nov 1, 2011·The Journal of Allergy and Clinical Immunology·Adaikalavan RamasamyDeborah L Jarvis
Oct 11, 2012·Frontiers in Pharmacology·Zheng Quan TohPaul V Licciardi
Mar 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margit WeghoferSusanne Vrtala

❮ Previous
Next ❯

Citations

Jul 1, 2015·Allergy, Asthma & Immunology Research·En Chih LiaoJaw Ji Tsai
Aug 22, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Takashi IshiiNaomi Yamashita

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
PCR
Genotyping
Assay
enzyme-linked immunosorbent assay
genetic modification

Software Mentioned

SPSS Sample Power
SPSS

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.