Abstract
Solid-organ transplant recipients (OTRs) are at an increased risk for skin cancer. Prior studies have demonstrated a reduced incidence of skin cancer in renal OTRs treated with sirolimus. However, little information exists on the use of sirolimus for the prevention of skin cancer in nonrenal OTRs or those already diagnosed as having a posttransplant cancer. To compare subsequent skin cancer formation in a mixed-organ cohort of OTRs who were or were not treated with sirolimus after developing a posttransplant index cancer of any type. A 9-year retrospective cohort study at 2 academic tertiary care centers. Electronic medical records were reviewed for OTRs diagnosed as having a posttransplant cancer of any type to determine the type of organ transplanted, pretransplant and posttransplant cancer, and immunosuppressive medications. Patients underwent transplant from January 1, 2000, to December 31, 2008. Data were collected from July 30, 2011, to December 31, 2012, when follow-up was completed, and analyzed from April 28, 2013, to October 4, 2014. Factors associated with subsequent skin cancer development were evaluated via multivariate Cox regression analysis. Of 329 OTRs with an index posttransplant cancer (100 women and 229 men;...Continue Reading
Citations
Oct 28, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Vikas R DharnidharkaKrista L Lentine
Jul 23, 2016·Clinical Transplantation·Mimi TranP Régine Mydlarski
Jan 19, 2017·Transplantation·Emilie DucrouxJacques Dantal
May 31, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Mittal, O R Colegio
Jul 18, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jacques DantalUNKNOWN TUMORAPA Study Group
Aug 16, 2018·Dermatologic Therapy·Mitchell HeroldKiran Motaparthi
Nov 1, 2017·The British Journal of Dermatology·C A HarwoodUNKNOWN KeraCon Consortium
Nov 1, 2017·The British Journal of Dermatology·M BlombergUNKNOWN NCI Keratinocyte Carcinoma Consortium
Jun 23, 2019·International Journal of Dermatology·Kevin PhanAnousha Yazdabadi
Nov 27, 2019·JCO Oncology Practice·Saad Ahmad AliRuemu Ejedafeta Birhiray
Dec 14, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·E I PlasmeijerJ N Bouwes Bavinck
May 27, 2017·Oncotarget·Mikhail V Blagosklonny
Jan 10, 2018·Oncotarget·Olga V Leontieva, Mikhail V Blagosklonny
Jul 2, 2020·Renal Failure·Susan L MurrayPeter J Conlon
Apr 16, 2019·Journal of Skin Cancer·Nikolai GrägerImke Satzger
Mar 5, 2019·F1000Research·Abraham Cohen-BucayJean M Francis
Jan 23, 2021·Current Oncology·Luca Paoluzzi, Thomas J Ow
Feb 18, 2020·Oral Oncology·Kristin BibeeDan P Zandberg
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Reason WilkenMary L Stevenson
Aug 14, 2021·Journal of the American Academy of Dermatology·Jennifer R DusendangLisa J Herrinton