Association of SIRT1 and HMGA1 expression in non-small cell lung cancer

Oncology Letters
Shuang-Yan Lin, Fang Peng

Abstract

The roles of Silent mating type information regulation 2 homolog 1 (SIRT1) and High mobility group A1 (HMGA1) in human diseases have been extensively studied separately; however, to the best of our knowledge, the current study is the first to report on their interrelationship in lung cancer. The association of SIRT1 and HMGA1 in non-small cell lung cancer (NSCLC) was investigated by evaluating their expression and prognostic significance in 260 patients with NSCLC using immunohistochemistry. SIRT1 and HMGA1 expression were found to be significantly correlated with each other (P<0.001), and both were significantly associated with clinicopathological parameters, including histological type and degree of differentiation. In squamous cell carcinoma (SCC), SIRT1(+) specimens were significantly associated with shorter overall survival (OS) time (P=0.019). However, in patients with adenocarcinoma (AD), no association was identified between SIRT1 and OS. In addition, HMGA1(+) specimens were significantly associated with poor differentiation (P=0.028), and were more frequent in SCC than AD (P=0.015). However, HMGA1 was not associated with OS on univariate Cox regression analysis or Kaplan-Meier analysis (both P>0.05). SIRT1/HMGA1 coexpr...Continue Reading

References

Mar 1, 1994·Trends in Genetics : TIG·R GrosschedlJ Pagel
Jul 4, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J NiklinskiE Pluygers
Jun 17, 2003·Carcinogenesis·Valeria MasciulloAlfredo Fusco
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hwei-Ling ChengKatrin F Chua
Jun 11, 2004·Annual Review of Biochemistry·Gil Blander, Leonard Guarente
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gennaro ChiappettaAlfredo Fusco
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrei KuzmichevDanny Reinberg
Dec 13, 2005·Cell Death and Differentiation·G M PierantoniA Fusco
Mar 8, 2006·The Journal of Pathology·V K SarhadiS Anttila
Feb 10, 2007·The Journal of Clinical Investigation·Giovanna Maria PierantoniAlfredo Fusco
Sep 7, 2007·Biotechnology Journal·Walter StünkelJeanette Wood
Nov 16, 2007·Nature Reviews. Cancer·Alfredo Fusco, Monica Fedele
Oct 15, 2008·Molecular Cell·Rui-Hong WangChu-Xia Deng
May 20, 2009·Cell·Jan-Philipp Kruse, Wei Gu
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eun Jung ChaKyu Yun Jang
Aug 4, 2009·Neoplasia : an International Journal for Oncology Research·Ruo-Chia TsengYi-Ching Wang
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Apr 8, 2010·Molecular Cancer Therapeutics·Barrie PeckEric W-F Lam
Jun 10, 2010·Cancer Research·Francesco EspositoAlfredo Fusco
Nov 20, 2012·Oncology Letters·Hyun Jin BaeSuk Woo Nam
Jan 12, 2013·Cell Death and Differentiation·M KracikovaS A Aaronson
May 25, 2013·Pathology, Research and Practice·Sang Jae NohMyoung Ja Chung
Sep 7, 2013·Korean Journal of Pathology·Wonkyung JungBaek-Hui Kim

❮ Previous
Next ❯

Citations

Jan 10, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Cuiling QiBo Wei
Jan 8, 2019·Journal of Cellular and Molecular Medicine·Yuhong WangLingchuan Guo
Feb 6, 2018·World Journal of Surgical Oncology·Yue-Ya LiangYong-Yao Gu
Jul 20, 2018·EMBO Reports·Luis Filipe Costa-MachadoPablo J Fernandez-Marcos
May 7, 2019·Journal of Drug Targeting·Bin ZhaoPeng Shang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Shuang-Shuang NiJin-Lin Wang
International Journal of Clinical and Experimental Pathology
Wei-Jun ChenXiu-Wen Wang
© 2021 Meta ULC. All rights reserved