Association of six genetic variants with myocardial infarction

International Journal of Molecular Medicine
Reiko MatsuokaYoshiji Yamada

Abstract

Although various genes that confer susceptibility to myocardial infarction (MI) have been identified for Caucasian populations in genome-wide association studies (GWAS), genetic variants related to this condition in Japanese individuals have not been identified definitively. The aim of the present study was to examine an association of MI in Japanese individuals with 29 polymorphisms identified as susceptibility loci for MI or coronary artery disease in Caucasian populations by meta-analyses of GWAS. The study subjects comprised 1,824 subjects with MI and 2,329 controls. Genotypes of the polymorphisms were determined by Luminex bead-based multiplex assay. To compensate for multiple comparisons, we adopted the criterion of a false discovery rate (FDR) of <0.05 for statistical significance for association. Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs1241340...Continue Reading

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Citations

Feb 1, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Jikuang ZhaoYi Huang
May 13, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jianyi YinMark Donowitz
Nov 7, 2019·Current Pharmaceutical Design·Huilei ZhengXiaoling Qiu
Jul 17, 2015·International Journal of Molecular Medicine·Julian Banerji
Sep 26, 2015·Biomedical Reports·Chikara UeyamaYoshiji Yamada
Feb 20, 2016·Biomedical Reports·Yuichiro YamaseYoshiji Yamada
Apr 2, 2016·Schizophrenia Bulletin·Ingrid DiesetUnn K Haukvik
Jul 15, 2015·Biomedical Reports·Yuichiro YamaseYoshiji Yamada
Sep 27, 2018·Brain : a Journal of Neurology·Nanako HamadaKoh-Ichi Nagata
Feb 19, 2021·Human Mutation·Gijs A C FrankenJeroen H F de Baaij
Aug 22, 2021·Journal of Cellular and Molecular Medicine·Yan-Yan LiYang-Yang Zhang

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