Association of skin autofluorescence with plaque vulnerability evaluated by optical coherence tomography in patients with cardiovascular disease

Atherosclerosis
Yusuke FujinoSunao Nakamura

Abstract

Accumulation of advanced glycation end products (AGEs) can be measured non-invasively by skin autofluorescence (SAF) whose values are elevated in patients with cardiovascular disease (CVD). Optical coherence tomography (OCT) is an intravascular imaging modality that could allow visualization of plaque composition. We aim to examine the relationship between SAF and plaque composition evaluated by frequency-domain OCT in patients with CVD. We prospectively enrolled 108 patients with CVD, who underwent OCT images during percutaneous coronary intervention (PCI). We divided the population into two groups: high SAF group (greater than or equal to 2.6) and low SAF one (less than 2.6). OCT findings were then compared between high and low SAF groups. The high SAF group showed much more thin cap fibroatheroma (TCFA), and calcified or ruptured plaques compared to the low SAF group. In multivariable analysis, low-density lipoprotein-cholesterol (LDL) (odds ratio: 1.15; 95% confidence interval: 1.00 to 1.32; p = 0.043), TG (OR for 10 mg/dl increase: 1.04; 95% confidence interval: 1.01 to 1.13; p = 0.016), and SAF (4.28; 1.86 to 9.84; p < 0.001) were independent correlates of TCFA, whereas SAF (2.61; 1.02 to 6.70; p = 0.047), estimated glome...Continue Reading

Citations

May 9, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Amra JujićMartin Magnusson
Aug 2, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Sho-Ichi Yamagishi
Aug 14, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nobuhiro TaharaYoshihiro Fukumoto
Nov 8, 2018·Annals of Vascular Diseases·Sho-Ichi Yamagishi, Takanori Matsui
Jan 3, 2021·Journal of Diabetes and Its Complications·Saad RojuballyVincent Rigalleau
Jun 18, 2021·Advanced Drug Delivery Reviews·Alexandros Marios SofiasTwan Lammers
Sep 17, 2021·World Journal of Surgical Oncology·Maciej KrasnodębskiMichał Grąt

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