Association of SLC30A8 gene polymorphism with type 2 diabetes, evidence from 46 studies: a meta-analysis

Endocrine
Mengdi FanChao Zheng

Abstract

The solute carrier family 30 member 8 (SLC30A8) gene may be involved in the development of type 2 diabetes mellitus (T2DM) through disrupting β-cell function. The aim of this study was to assess the association between SLC30A8 rs13266634 polymorphism and susceptibility to T2DM. We searched all reports regarding the association between SLC30A8 rs13266634 polymorphism and T2DM risk through Pubmed, Embase, and the Cochrane Library for English language reports and Chongqing VIP database, Wanfang data, CBMDisc, and CNKI for Chinese language studies. Allelic and genotype comparisons between cases and controls were evaluated, and odds ratios with 95 % confidence intervals were used to assess the strength of their association. A random effects model was selected. Publication bias was estimated using Begg's test. Forty-six studies were included in the analysis with a total of 71,890 cases and 96,753 controls. This meta-analysis suggests that SLC30A8 (rs13266634) polymorphism was associated with T2DM risk. Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on T2DM in an African popu...Continue Reading

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Citations

Jun 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Deborah Brunke-ReeseDavid I Soybel
Aug 29, 2017·BioFactors·Robertina GiacconiMauro Provinciali
Jun 19, 2020·Journal of Diabetes and Metabolic Disorders·Ali Reza SoltanianMohammad Ebrahim Ghaffari
Feb 14, 2019·Inflammopharmacology·Tianjiao ZhaoWei Wei
Feb 13, 2018·Metallomics : Integrated Biometal Science·Pauline ChabosseauGuy A Rutter
Apr 3, 2019·International Journal of Endocrinology·Qiong HuangZhicheng Gong

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